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Record W3097986605 · doi:10.1016/j.sbi.2020.08.004

Discovery of allosteric binding sites by crystallographic fragment screening

2020· review· en· W3097986605 on OpenAlexfundno aff
T. Krojer, James S. Fraser, F. von Delft

Bibliographic record

VenueCurrent Opinion in Structural Biology · 2020
Typereview
Languageen
FieldComputer Science
TopicComputational Drug Discovery Methods
Canadian institutionsnot available
FundersNational Institute of General Medical SciencesEshelman Institute for Innovation, University of North Carolina at Chapel HillBioXFEL Science and Technology CenterMSD Life Science Foundation, Public Interest Incorporated FoundationJanssen BiotechInnovative Medicines InitiativeCanada Foundation for InnovationOntario Ministry of Economic Development and InnovationWellcome TrustGenome CanadaAbbViePfizerNorges IdrettshøgskoleBoehringer Ingelheim
KeywordsAllosteric regulationDrug discoveryComputational biologyFunction (biology)Protein functionFragment (logic)Allosteric enzymeBinding sitePlasma protein bindingChemistryBiologyComputer scienceBioinformaticsBiochemistryGeneticsReceptor

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.988
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.108
GPT teacher head0.414
Teacher spread0.306 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations43
Published2020
Admission routes1
Has abstractno

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