Photoencapsulated-BMP2 in vIsible Light-Cured Thiol-Acrylate Hydrogels for Craniofacial Bone Tissue Engineering
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Post-publication record
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Abstract
Aim: The study aimed to examine the impact of crosslinking BMP2 in biodegradable visible light-cured thiol-acrylate hydrogels. Materials & methods: BMP2 was photoencapsulated in 10 wt% PEG-diacrylate hydrogels with or without immortalized mouse bone marrow stromal cells (BMSC). Results & conclusion: Photoencapsulated-BMSC with BMP2 (BMBMP2) showed a significantly (p < 0.05) increased level in metabolic activity, by 54.61%, compared with photoencapsulated-BMSC at day 3. Furthermore, BMBMP2 groups showed significantly increased levels in ALP activity compared with BMSC at days, 1, 3, 7 (p < 0.01) and 10 (p < 0.05). This study shows promising results photoencapsulating BMP2 in thiol-acrylate hydrogels for craniofacial bone tissue engineering applications.
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The record
- Venue
- Regenerative Medicine
- Topic
- Bone Tissue Engineering Materials
- Field
- Engineering
- Canadian institutions
- —
- Funders
- Canadian Bureau for International Education
- Keywords
- Self-healing hydrogelsAcrylateBone morphogenetic protein 2Tissue engineeringCraniofacialBiomedical engineeringMaterials scienceChemistryPolymer chemistryMedicineComposite materialPolymerCopolymerBiochemistry
- Has abstract in OpenAlex
- yes