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Record W3100745008 · doi:10.1063/5.0021844

Using mathematics to diagnose, cure, and predict cardiac arrhythmia

2020· article· en· W3100745008 on OpenAlexaff
Leon Glass

Bibliographic record

VenueChaos An Interdisciplinary Journal of Nonlinear Science · 2020
Typearticle
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsMcGill University
Fundersnot available
KeywordsAtrial fibrillationCardiac arrhythmiaCardiologyInternal medicineSudden cardiac deathVentricular fibrillationRisk stratificationMedicineFibrillationAlgorithmMathematics

Abstract

fetched live from OpenAlex

Mathematics can be used to analyze and model cardiac arrhythmia. I discuss three different problems. (1) Diagnosis of atrial fibrillation based on the time intervals between subsequent beats. The probability density histograms of the differences of the intervals between consecutive beats have characteristic shapes for atrial fibrillation. (2) Curing atrial fibrillation by ablation of the core of rotors. Recent clinical studies have proposed that ablating the core of rotors in atrial tissue can cure atrial fibrillation. However, the claims are controversial. One problem that arises relates to difficulties associated with developing algorithms to identify the core of rotors. In model tissue culture systems, heterogeneity in the structure makes it difficult to unambiguously locate the core of rotors. (3) Risk stratification for sudden cardiac death (SCD). Despite numerous clinical studies, there is still a need for improved criteria to assess the risk of SCD. I discuss the possibility of using the dynamics of premature ventricular complexes to help make predictions. The development of wearable devices to record and analyze cardiac rhythms offers new prospects for the diagnosis and treatment of cardiac arrhythmia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.726
Threshold uncertainty score0.531

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.357
Teacher spread0.318 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2020
Admission routes1
Has abstractyes

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Same venueChaos An Interdisciplinary Journal of Nonlinear ScienceSame topicCardiac electrophysiology and arrhythmiasFrench-language works237,207