Nidogen 1 regulates proliferation and migration/invasion in murine claudin‑low mammary tumor cells
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Nidogen 1 (NID1) is a glycoprotein found in basement membranes involved in cross‑linking collagen IV and laminin. The role of NID in breast cancer has only been evaluated in a small number of studies and the findings of these studies have been inconsistent. Our previous work revealed that highly tumorigenic murine mammary tumor cells express high levels of <em>Nid1</em> while weakly tumorigenic mammary tumor cells express low levels of <em>Nid1</em>. To investigate Nid1, two stable knockdown lines were created, and <em>Nid1</em> knockdown was confirmed at both the mRNA and protein level. <em>Nid1</em> knockdown significantly reduced cell proliferation and migration/invasion and these reductions in proliferation and migration/invasion could be rescued by conditioned media containing NID1 protein. The reduced migration/invasion observed in the <em>Nid1</em> knockdown cells was not associated with significant alterations in the epithelial gene <em>Cdh1</em> or the mesenchymal genes <em>Snai1</em>, <em>Snai2</em>, <em>Twist1</em>, <em>Twist2</em>, <em>Zeb1</em> and <em>Zeb2</em>. Therefore, suppression of Nid1 expression reduces proliferation and migration/invasion in claudin‑low murine mammary tumor cells.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it