Bibliographic record
Abstract
An efficient method for allylation of a sterically hindered alcohol in the presence of base-sensitive functionality (cf. 1 to 2) has been developed (Tetrahedron Lett. 2012, 53, 1319) by Richard B. Silverman at Northwestern University. Mark S. Taylor at the University of Toronto found (J. Am. Chem. Soc. 2012, 134, 8260) that borinic acid 4 catalyzed the monofunctionalization of diols and carbohydrates such as 3. The selective functionalization of unprotected peptides can be challenging, but Man-Kin Wong at Hong Kong Polytechnic University and Chi-Ming Che at the University of Hong Kong have shown (J. Am. Chem. Soc. 2012, 134, 2589) that selective N-terminal functionalization can be achieved with the alkynyl ketene 7, which allows for subsequent derivitization of the acylated products (e.g., 8) via click reactions with azides. To formylate amines such as morpholine (9), an N-heterocyclic carbene (e.g., 10) catalyzed procedure that utilizes CO2 and polymethylhydrosiloxane (PMHS) has been developed (J. Am. Chem. Soc. 2012, 134, 2934) by Thibault Cantat at the CEA in France. For the protection of acyclic amino acid derivatives, Eiji Tayama at Niigata University has reported (Tetrahedron Lett. 2012, 53, 1373) a new protecting group, 1,2-dimethoxy-4,5-dimethylene, that is installed by double alkylation and can be removed with, for example, ethyl chloroformate to produce the corresponding carbamate (e.g., 12 to 13). As far as protecting groups go, ethers can be especially challenging to remove; however, a new procedure for the oxidative cleavage of glycol ethers, including dioxane, has been developed (Org. Lett. 2012, 14, 3218) by Zhong-Quan Liu at Lanzhou University. This copper-catalyzed procedure employs carboxylic acids such as 14 and produces alkoxymethoxy esters 15. The cleavage of unactivated ethers such as dibutyl ether as a means to alkylate sulfonamides (cf. 16) has been reported (Synlett 2012, 595) by Wei Zeng at South China University of Technology. Protecting groups that are thermally labile offer the ability to achieve deprotection without added reagents. A new thermolabile protecting group has been developed (Tetrahedron Lett. 2012, 53, 666) by Marcin K. Chmielewski at the Polish Academy of Sciences based on 2-pyridyl-N-(2,4-difluorobenzyl)aminoethyl carbonates.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.018 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".