Relapsing Polychondritis and Large-vessel Vasculitis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Relapsing polychondritis (RP) is a rare and in some cases fatal systemic inflammatory rheumatic disorder characterized by episodic inflammation of cartilage1,2,3. Common clinical features include chondritis of the nasal bridge, auricular cartilage, ocular and inner ear inflammation, arthritis, and involvement of the tracheobronchial tree. Destruction of the laryngeal and tracheal cartilage rings may lead to collapse of the airways and is associated with a high risk of morbidity and mortality4. Its rarity often leads to considerable delay in establishing a diagnosis1,2,3. RP may present with similar clinical features to other autoimmune rheumatic diseases such as granulomatosis with polyangiitis (GPA) and eosinophilic GPA (eGPA). Treatment for RP is usually with corticosteroids and immunosuppressive drugs but there are no randomized trials or specific guidelines for management, so treatment remains empirical and based on expert opinion5. Vascular involvement in RP ranges from 5% to 25%. The disease can affect small, medium, and large vessels. Although aortic involvement is particularly rare, it is associated with significant morbidity and mortality. The largest study in the literature evaluating aortic involvement by Le Besnerais, et al of 172 patients with RP found a prevalence of nonatheromatous aortic disease in 11 patients (6.4%)6. The pattern of … Address correspondence to Prof. D. D’Cruz, Consultant Rheumatologist, Louise Coote Lupus Unit, Guy’s Hospital, London SE1 9RT, UK. Email: david.d’cruz{at}kcl.ac.uk.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.005 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it