Robust Constrained Drug Dosage Regulation of Acute Inflammation Response Under Disturbances
Why this work is in the frame
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Bibliographic record
Abstract
Mathematical modelling of the biological processes, diseases and organs are important for the model-based control of diseases. Due to unmodeled dynamics, unknown and external disturbances, the performance of controllers based on these models are degraded for the accurate control. Therefore, robust controllers are need especially for the applications on patients. Inflammation, the cause of many complex biological phenomena and diseases, is a nonlinear process that is difficult to control. In this paper, continuous-time sliding-mode controller has been designed for the control of acute inflammation response (AIR) and antibacterial drug infusion under external disturbances both for septic and aseptic cases. Sliding-mode controller (SMC) is mostly used to control nonlinear systems against external disturbances and parametric uncertainties. Beside the control signal generation, we propose constraints on the control signals based on the clinical experiences such that the applied control signal is suitable for the health and improves the performance of the controller. Due to the multiple equilibrium point on the behavior of the acute inflammation response, it is difficult to design such model-based controllers without input constraints. In the numerical applications, septic death case and aseptic death case with disturbances are controlled and acceptable performances are obtained for future clinical applications.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it