118 Functional amino acid supplementation, regardless of dietary protein content, improves growth performance, acute-phase response, and bacterial shedding in Salmonella-challenged pigs
Bibliographic record
Abstract
Abstract The present study investigated the interactive effect of functional amino acid (AA) supplementation and dietary protein level on growth performance and immune status in Salmonella-challenged pigs. Thirty-two growing pigs (8 pigs/treatment; 13.9 ± 0.82 kg initial body weight) had ad libitum access to 1 of 4 experiment diets in a 2×2 factorial arrangement with factors of dietary protein (LP: Low, 16% protein vs. High: HP, 20% protein) and 2 levels of functional AA supply (AA-: basal vs. AA+: Thr, Met, and Trp provided at 20% above requirement). After 7 d of adaptation, pigs were orally inoculated with saline containing Salmonella typhimurium (ST). Performance parameters [average daily gain (ADG), feed intake, and gain:feed (GF)] were measured in the pre- and post-inoculation periods. Blood samples were collected on d0, 4 and 7 post-inoculation for serum haptoglobin and albumin analysis. Shedding of ST (d1, 2, 4 and 6 post-inoculation) and quantification in digesta (ileum, cecum and colon; d7 post-inoculation) were analyzed. There was no effect of diet on pre-inoculation performance (P > 0.05). Pigs fed AA+ showed increased ADG (0.457 vs. 0.298 ± 0.051 kg/d; P < 0.05) and a trend for improved GF (0.67 vs. 0.40 ± 0.07 kg/kg; P < 0.10) post-inoculation compared to AA- regardless of dietary protein level. Feeding AA+ increased overall albumin levels (35.7 vs. 34.2 ± 0.9 g/L; P < 0.05) and decreased overall haptoglobin levels (1.64 vs. 1.81 ± 0.12 g/L; P < 0.05) and decreased overall shedding score of ST (2.27 vs. 2.51 ± 0.09; P < 0.05) compared to AA-. The ST counts in cecal digesta increased (2.78 vs. 2.23 ± 0.18 Log10 cfu/g; P < 0.05) in pigs fed HP compared to LP-fed pigs and ST counts in colon were reduced (2.08 ± 0.18 vs. 2.61 ± 0.19 Log10 cfu/g; P < 0.05) in AA+ compared to AA- pigs. Supplementation of diets with specific functional AA improved performance and health status of pigs when exposed to an enteric disease challenge.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".