Memory complaints are associated with impaired working memory and reduced frontal cortical thickness in mid‐life surgically menopausal women
Bibliographic record
Abstract
Abstract Background Alzheimer’s disease (AD)‐related brain pathology is observed in participants within the normal ranges of cognitive assessments (Delacourte et al., 1999). Consequently, there is increased interest in subjective cognitive decline (SCD), a self‐experienced decline in cognition, as an early risk factor (Jessen et al., 2014). SCD is associated with earlier conversion to mild cognitive impairment (MCI) and AD (Jessen et al., 2010; Reisberg et al., 2010), poorer performance on cognitive tasks, and cortical thinning in AD‐related regions (Schultz et al., 2015; Sánchez‐Benavides et al., 2018). Women with surgical menopause prior to age 50 have an increased risk of AD (Rocca et al., 2007). Women with bilateral salpingo‐oophorectomy (BSO) without estradiol (E2) therapy in mid‐life show decreases in WM performance and volumetric declines in the frontal cortex and hippocampus compared to controls (Almey et al., 2018; Gervais et al., 2018). Method The current study evaluated the association of memory complaints with WM performance and frontal cortical thickness in a mid‐life cohort of at‐risk women with BSO. Participants with memory complaints (n = 42) and without (n = 30) completed demographics and neuropsychological tasks to assess WM. A subset of these participants with memory complaints (n = 11) and without (n = 14) were scanned using a 3T Siemens scanner, and cortical thickness was obtained from T1‐weighted scans using CIVET 2.1.1 (Ad‐Dab’bagh et al., 2005). Analyses were performed using R 1.1.4 (R Core Team, 2018). Result Our analyses revealed participants with memory complaints performed significantly worse on WM tasks than those without. Furthermore, we found participants with memory complaints had significantly thinner cortices within the left ventrolateral prefrontal cortex (vlPFC), a region associated with WM (Badre & Wagner, 2007). Conclusion Our preliminary results demonstrate memory complaints are associated with impaired WM performance and frontal cortical thinning in women with BSO. The results suggest that women with surgical menopause and memory complaints show differences associated with SCD in WM function and frontal cortical structure at an early age (Wang et al., 2004). Ongoing research is evaluating effects of memory complaints on cognition and brain structure within spontaneously menopausal women in the COMPASS‐ND database (CCNA, 2020).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".