On invariant T cells and measles: A theory of “innate immune amnesia”
Bibliographic record
Abstract
Measles (aka rubeola) is a highly contagious disease caused by a single-stranded RNA virus belonging to the family Paramyxoviridae.Measles virus (MeV) caused major epidemics and claimed an estimated 2.6 million lives annually prior to 1963 when a measles vaccine was introduced.Immunization against measles is estimated to have prevented 23.2 million deaths between 2000 and 2018.Notwithstanding, MeV continues to ravage impoverished regions, especially in the aftermath of natural disasters.In addition, despite the availability of safe, effective and affordable vaccines against MeV, anti-vaccination sentiments have created vulnerable societal pockets, which can be troubling in light of the increasing ease of global travel.It is therefore not surprising that recent years have witnessed a multitude of measles outbreaks and that measles-associated deaths have been alarmingly on the rise.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.006 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".