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Record W31125859 · doi:10.1016/j.jad.2019.05.019

Una puerta abierta contra el VIH

2013· article· en· W31125859 on OpenAlexfundno aff
Carlos J. Martos Rodriguez

Bibliographic record

VenueMoleQla: revista de Ciencias de la Universidad Pablo de Olavide · 2013
Typearticle
Languageen
FieldMedicine
TopicHIV/AIDS oral health manifestations
Canadian institutionsnot available
FundersCanadian Institutes of Health Research
KeywordsHumanitiesPhilosophyHuman immunodeficiency virus (HIV)PhysicsBiologyVirology

Abstract

fetched live from OpenAlex

El Virus de Inmunodeficiencia Humano, VIH, es el causante del Sindrome de Inmunodeficiencia Adquirida o SIDA -pandemia mundial y de complicado tratamiento-. Durante decadas, cientificos de todo el mundo han tratado sin exito aparente erradicar por completo al virus -cura funcional- o de encontrar una vacuna eficiente. Investigadores espanoles, valiendose para ello de los componentes del sistema inmune que actuan como caballo de Troya, las celulas dendriticas, y su capacidad para presentar antigenos y activar el sistema inmunologico. Se pretendia asi inducir la respuesta inmune de manera eficiente presentando un antigeno del propio virus, que previamente se habia usado para infectar este tipo de celulas -del propio paciente- aunque inactivados por calor. Otras investigaciones, realizadas en la Universidad de Rockefeller, se centraban en el uso de combinaciones de anticuerpos neutralizantes con un diseno optimizado para actuar contra el virus y evitar en la medida de lo posible que la presion evolutiva ejercida sobre el mismo genere mutantes a los que sea imposible neutralizar.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score0.026

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.301
Teacher spread0.292 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2013
Admission routes1
Has abstractyes

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