The expression of the small heat shock protein Hsp25 in the embryonic chick cerebellum
Bibliographic record
Abstract
The embryonic chick is an ideal model for studying pattern formation in the cerebellum due to the easily accessible embryo at all stages of development. The newly-hatched chick is precocial - able to stand, walk and run within hours. Despite a similar length gestation, mouse pups are altricial (immature, immobile) at birth and locomotor development takes weeks: it is plausible that this difference in coordinated motor movement may be reflected in the timing of protein expression patterns in the cerebellum. In the present study, we used western blot analysis and immunohistochemistry to determine the expression of an additional Purkinje cell ‘patterning’ antigen - the small heat shock protein Hsp25. This embryonic expression precedes that seen in neonatal mice by nearly a week. The earlier/accelerated timing of these antigens in the embryonic chick cerebellum as compared to the mouse may reflect the precocial character (e.g. motor co-ordination, mobility) of chicks at hatch. This study will broaden our understanding of the specific patterning and organization of the developing avian cerebellum and provide the foundation for further studies designed to investigate the function of Hsp25 in cerebellar Purkinje cells. * Indicates faculty mentor.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".