The Comparison of Anti-inflammatory and Analgesic Effect of Diclofenac Alone with Combined Treatment with Diclofenac and Serratiopeptidase in Patients having Osteoarthritis of Knee Joint
Bibliographic record
Abstract
Oral proteolytic enzymes like serratiopeptidase are very commonly used by clinicians either alone or in combination with non-steroidal anti-inflammatory drugs for analgesia and anti-inflammatory purpose. As the activity of these drugs is not proved in trials, and they are not listed in any country's official pharmacopoeia, it was planned to study their effect in osteoarthritis patients. Two groups (n= 30 each) of diagnosed knee osteoarthritis patients, were treated with diclofenac 50 mg twice a day (BID) and serratiopeptidase 10mg three times a day (TID) + Diclofenac 50 mg BID for two weeks. The pain and difficulty in daily activities were assessed by Visual Analogue Scale (VAS) and Western Ontario and Mc Masters Universities Osteoarthritis (WOMAC OA) index scale before and after the treatment. Highly significant improvement in both scales was seen in both groups. There was no statistically significant difference in the improvements found in both groups. Addition of serratiopeptidase has not potentiated analgesic and anti-inflammatory effects of diclofenac. Thus, the analgesic and anti-inflammatory efficacy of serratiopeptidase are not proved.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".