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Preservation of Histology by Phenol-Based Fixative: Mini Review of Recent Findings

2021· article· en· W3119163686 on OpenAlexaff
S M Niazur Rahman, Tanbira Alam, Nazmun Nahar Alam

Bibliographic record

VenueInternational Journal of Morphology · 2021
Typearticle
Languageen
FieldEngineering
TopicAnatomy and Medical Technology
Canadian institutionsQueen's UniversityUniversity of Toronto
Fundersnot available
KeywordsFixativeFixation (population genetics)Cadaveric spasmHistologyPhenolBiomedical engineeringBiologyAnatomyPathologyMedicineChemistryStaining

Abstract

fetched live from OpenAlex

In surgical and anatomical training, use of cadaver remains the most ideal technique.Standard formaldehyde solution preserves cadaveric tissues for an extended period comparing to the unfixed tissues.However, it fails to retain the natural texture, color, and biomechanical features.Phenol based soft embalming methods were developed to maintain these properties, while simultaneously decreasing the biohazard risk.Soft embalming techniques have made the bodies more 'lifelike' and wellfitted for training.Though phenol fixation displays rewarding morphological maintenance, we have scanty evidences on the histological preservation.This mini review primarily discussed the latest reports regarding the effect of phenol-based fixation on the tissue histology.Published literatures revealed phenol-based fixation displayed comparable histological preservation to that ofgold standard paraformaldehyde-based solution.It was concluded that phenol-based solution is an excellent fixative used to preserve tissues for microscopic analysis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.004
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.282
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2021
Admission routes1
Has abstractyes

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