Early Onset of Hepatosplenic T-cell Lymphoma Following Azathioprine Cessation in Ulcerative Colitis: A Case Report
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Hepatosplenic T Cell Lymphoma (HSTCL) is a rare but deadly form of non-Hodgkin’s lymphoma which is increasingly reported in the context of chronic immunosuppression in patients with solid organ transplant, lymphoproliferative disorder, or inflammatory bowel disease (IBD). It is of note that there is an association between the development of HSTCLand the use of thiopurines or anti-tumor-necrosis alpha inhibitors (anti-TNFs) in patients with IBD. The development of HSTCL is usually concurrent with the use of a thiopurine and an anti-TNF. We report a case of a young male with extensive Ulcerative Colitis who developed HSTCL eight months following cessation of azathioprine monotherapy. This case highlights the need for consideration of potential significant adverse side effects such as HSTCL when prescribing azathioprine, particularly in the described demographic of a young male. Furthermore, the risk for HSTCL can persist despite cessation of azathioprine.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it