Early Onset of Hepatosplenic T-cell Lymphoma Following Azathioprine Cessation in Ulcerative Colitis: A Case Report
Bibliographic record
Abstract
Hepatosplenic T Cell Lymphoma (HSTCL) is a rare but deadly form of non-Hodgkin’s lymphoma which is increasingly reported in the context of chronic immunosuppression in patients with solid organ transplant, lymphoproliferative disorder, or inflammatory bowel disease (IBD). It is of note that there is an association between the development of HSTCLand the use of thiopurines or anti-tumor-necrosis alpha inhibitors (anti-TNFs) in patients with IBD. The development of HSTCL is usually concurrent with the use of a thiopurine and an anti-TNF. We report a case of a young male with extensive Ulcerative Colitis who developed HSTCL eight months following cessation of azathioprine monotherapy. This case highlights the need for consideration of potential significant adverse side effects such as HSTCL when prescribing azathioprine, particularly in the described demographic of a young male. Furthermore, the risk for HSTCL can persist despite cessation of azathioprine.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.005 | 0.004 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".