An Ensemble Learning Approach Based on Diffusion Tensor Imaging Measures for Alzheimer’s Disease Classification
Why this work is in the frame
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Bibliographic record
Abstract
Recent advances in neuroimaging techniques, such as diffusion tensor imaging (DTI), represent a crucial resource for structural brain analysis and allow the identification of alterations related to severe neurodegenerative disorders, such as Alzheimer’s disease (AD). At the same time, machine-learning-based computational tools for early diagnosis and decision support systems are adopted to uncover hidden patterns in data for phenotype stratification and to identify pathological scenarios. In this landscape, ensemble learning approaches, conceived to simulate human behavior in making decisions, are suitable methods in healthcare prediction tasks, generally improving classification performances. In this work, we propose a novel technique for the automatic discrimination between healthy controls and AD patients, using DTI measures as predicting features and a soft-voting ensemble approach for the classification. We show that this approach, efficiently combining single classifiers trained on specific groups of features, is able to improve classification performances with respect to the comprehensive approach of the concatenation of global features (with an increase of up to 9% on average) and the use of individual groups of features (with a notable enhancement in sensitivity of up to 11%). Ultimately, the feature selection phase in similar classification tasks can take advantage of this kind of strategy, allowing one to exploit the information content of data and at the same time reducing the dimensionality of the feature space, and in turn the computational effort.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it