Challenges and Opportunities in the Evaluation of Nutraceuticals in Cardiovascular Diseases
Bibliographic record
Abstract
F ood supplements that provide putative physi- ologic benefits, broadly termed "nutraceuticals," have long intertwined with the history of medicine.Many of the most used cardiovascular drugs today, including aspirin, digoxin, and statins, were identified from dietary food sources that were historically used as natural treatments for a broad number of aliments.The market for nutritional supplements and nutraceuticals is huge, with over $120 billion USD in global sales in 2019.Although the health benefits of nutraceuticals are widely touted by enthusiasts, hard data from rigorously conducted trials supporting improvement in clinically relevant outcomes are scarce.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.013 | 0.026 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.003 | 0.007 |
| Scholarly communication | 0.005 | 0.006 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.044 | 0.032 |
| Insufficient payload (model declined to judge) | 0.008 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".