Extracting Drug Names and Associated Attributes From Discharge Summaries: Text Mining Study
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
BACKGROUND: Drug prescriptions are often recorded in free-text clinical narratives; making this information available in a structured form is important to support many health-related tasks. Although several natural language processing (NLP) methods have been proposed to extract such information, many challenges remain. OBJECTIVE: This study evaluates the feasibility of using NLP and deep learning approaches for extracting and linking drug names and associated attributes identified in clinical free-text notes and presents an extensive error analysis of different methods. This study initiated with the participation in the 2018 National NLP Clinical Challenges (n2c2) shared task on adverse drug events and medication extraction. METHODS: The proposed system (DrugEx) consists of a named entity recognizer (NER) to identify drugs and associated attributes and a relation extraction (RE) method to identify the relations between them. For NER, we explored deep learning-based approaches (ie, bidirectional long-short term memory with conditional random fields [BiLSTM-CRFs]) with various embeddings (ie, word embedding, character embedding [CE], and semantic-feature embedding) to investigate how different embeddings influence the performance. A rule-based method was implemented for RE and compared with a context-aware long-short term memory (LSTM) model. The methods were trained and evaluated using the 2018 n2c2 shared task data. RESULTS: The experiments showed that the best model (BiLSTM-CRFs with pretrained word embeddings [PWE] and CE) achieved lenient micro F-scores of 0.921 for NER, 0.927 for RE, and 0.855 for the end-to-end system. NER, which relies on the pretrained word and semantic embeddings, performed better on most individual entity types, but NER with PWE and CE had the highest classification efficiency among the proposed approaches. Extracting relations using the rule-based method achieved higher accuracy than the context-aware LSTM for most relations. Interestingly, the LSTM model performed notably better in the reason-drug relations, the most challenging relation type. CONCLUSIONS: The proposed end-to-end system achieved encouraging results and demonstrated the feasibility of using deep learning methods to extract medication information from free-text data.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it