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Consideração Ética sobre a Edição Genética em Seres Humanos

2021· article· pt· W3129888643 on OpenAlexaff
Thiago Ferreira de Toledo

Bibliographic record

VenueBrazilian Journal of Forensic Science Medical Law and Bioethics · 2021
Typearticle
Languagept
FieldHealth Professions
TopicEthics in medical practice
Canadian institutionsArtificial Intelligence in Medicine (Canada)
Fundersnot available
KeywordsPhilosophyHumanities

Abstract

fetched live from OpenAlex

A edição genética em seres humanos incita várias reflexões sobre qual deve ser o papel que a ciência deve desempenhar e quais os seus limites de atuação. Frente a essa problemática, esse ensaio teórico objetiva fornecer argumentos sobre as graves implicações éticas que tais práticas podem resultar. Como principal ponto argumentativo, será levado em conta um dos princípios éticos superiores apontado pela Ciência Logosófica: a tolerância. Nesse sentido, considerando esse princípio ético, é argumentado o por que as Ciências Biológicas não devem se ocupar com questões relacionadas a alteração dos genes. Para isso, são apresentados pontos de vista de autores a favor, e então, contrasto com outros fundamentos. A conclusão é a de que, dado os riscos e as incertezas com esses procedimentos, é mais prudente a ciência não se ocupar com essa prática.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.018
metaresearch head score (Gemma)0.029
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.018
Threshold uncertainty score0.094

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0180.029
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.002
Science and technology studies0.0050.045
Scholarly communication0.0080.006
Open science0.0020.005
Research integrity0.0060.006
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.109
GPT teacher head0.459
Teacher spread0.350 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2021
Admission routes1
Has abstractyes

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Same venueBrazilian Journal of Forensic Science Medical Law and BioethicsSame topicEthics in medical practiceFrench-language works237,207