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Consideração Ética sobre a Edição Genética em Seres Humanos

2021· article· pt· W3129888643 on OpenAlexaff
Thiago Ferreira de Toledo

Bibliographic record

VenueBrazilian Journal of Forensic Science Medical Law and Bioethics · 2021
Typearticle
Languagept
FieldHealth Professions
TopicEthics in medical practice
Canadian institutionsArtificial Intelligence in Medicine (Canada)
Fundersnot available
KeywordsPhilosophyHumanities

Abstract

fetched live from OpenAlex

A edição genética em seres humanos incita várias reflexões sobre qual deve ser o papel que a ciência deve desempenhar e quais os seus limites de atuação. Frente a essa problemática, esse ensaio teórico objetiva fornecer argumentos sobre as graves implicações éticas que tais práticas podem resultar. Como principal ponto argumentativo, será levado em conta um dos princípios éticos superiores apontado pela Ciência Logosófica: a tolerância. Nesse sentido, considerando esse princípio ético, é argumentado o por que as Ciências Biológicas não devem se ocupar com questões relacionadas a alteração dos genes. Para isso, são apresentados pontos de vista de autores a favor, e então, contrasto com outros fundamentos. A conclusão é a de que, dado os riscos e as incertezas com esses procedimentos, é mais prudente a ciência não se ocupar com essa prática.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.047
metaresearch head score (Gemma)0.163
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Science and technology studies, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMetaresearch, Science and technology studies, Research integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.776
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0470.163
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.002
Science and technology studies0.0050.036
Scholarly communication0.0000.001
Open science0.0020.001
Research integrity0.0020.023
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.109
GPT teacher head0.459
Teacher spread0.350 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2021
Admission routes1
Has abstractyes

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Same venueBrazilian Journal of Forensic Science Medical Law and BioethicsSame topicEthics in medical practiceFrench-language works237,207