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Record W3134103265 · doi:10.1016/s1470-2045(20)30756-7

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

2021· review· en· W3134103265 on OpenAlexaff
Philippe Moreau, Shaji Kumar, Jesús F. San Miguel, Faith E. Davies, Elena Zamagni, Nizar J. Bahlis, Heinz Ludwig, Joseph Mıkhael, Evangelos Terpos, Fredrik Schjesvold, Thomas G. Martin, Kwee Yong, Brian G.M. Durie, Thierry Façon, Artur Jurczyszyn, Surbhi Sidana, Noopur Raje, Niels W.C.J. van de Donk, Sagar Lonial, Michèle Cavo, Sigurður Y. Kristinsson, Suzanne Lentzsch, Roman Hájek, Kenneth C. Anderson, Cristina João, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt, Rafaël Fonseca, Annette Juul Vangsted, Katja Weisel, Rachid Baz, Vânia Hungria, Jesús G. Berdeja, Fernando Leal da Costa, Ângelo Maiolino, Anders Waage, David H. Vesole, Enrique M. Ocio, Hang Quach, Christoph Driessen, Joan Bladé, Xavier Leleu, Eloísa Riva, P. Leif Bergsagel, Jian Hou, Wee Joo Chng, Ulf‐Henrik Mellqvist, Dominik Dytfeld, Jean‐Luc Harousseau, Hartmut Goldschmidt, Jacob P. Laubach, Nikhil C. Munshi, Francesca Gay, Meral Beksaç, Luciano J. Costa, Martin Kaiser, Parameswaran Hari, Mario Boccadoro, Saad Z. Usmani, Sonja Zweegman, Sarah A. Holstein, Orhan Sezer, Simon J. Harrison, Hareth Nahi, Gordon Cook, María‐Victoria Mateos, S. Vincent Rajkumar, Meletios Α. Dimopoulos, Paul G. Richardson

Bibliographic record

VenueThe Lancet Oncology · 2021
Typereview
Languageen
FieldMedicine
TopicMultiple Myeloma Research and Treatments
Canadian institutionsUniversity of CalgaryHotel Dieu Hospital
FundersJanssen PharmaceuticalsMerck Sharp and DohmeGenesis PharmaGenentechNational Natural Science Foundation of ChinaTakeda Pharmaceutical CompanyAbbVieSanofiRocheNovartisGlaxoSmithKlineCelgeneBayerBristol-Myers SquibbAstraZenecaAmgenPfizer
KeywordsMultiple myelomaRefractory (planetary science)MedicineClinical trialInternal medicineOncologyClinical PracticeFamily medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.010
Threshold uncertainty score0.028

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.006
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0040.004
Science and technology studies0.0000.001
Scholarly communication0.0030.002
Open science0.0030.002
Research integrity0.0040.006
Insufficient payload (model declined to judge)0.0050.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.179
GPT teacher head0.423
Teacher spread0.244 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations268
Published2021
Admission routes1
Has abstractno

Explore more

Same venueThe Lancet OncologySame topicMultiple Myeloma Research and TreatmentsFrench-language works237,207