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Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial
François-Xavier Lescure, Hitoshi Honda, Robert Fowler, Jennifer Sloane Lazar, Genming Shi, Peter K. Wung, Naimish Patel, Owen Hagino, Ignacio J. Bazzalo, Marcelo Martín Casas, Sebastián A. Núñez, Yael Pere, Carlos M. Ibarrola, Marco A. Solis Aramayo, María Celia Cuesta, Andrea E. Duarte, Pablo Fernández, Maria A. Iannantuono, Erica A. Miyazaki, Javier P. Silvio, Darío Scublinsky, Alessandra Martins Bales, Daniela Catarino, Elie Fiss, Sara Mohrbacher, Victor Augusto Hamamoto Sato, Antonio Baylao, Adilson W. Cavalcante, Francini Guerra Correa, Celso A. de Andrade, Juvêncio José Duailibe Furtado, Nelson Ribeiro Filho, Valéria Telles, Leopoldo Tosi Trevelin, Ricardo Vipich, Rodrigo Boldo, Paula Borges, Suzana M. Lobo, Graziela Denardin Luckemeyer, Luana Machado, Maysa B. Alves, Ana Caroline Coutinho Iglessias, Marianna M. Lago, Daniel Wagner de Castro Lima Santos, Hugo Chapdelaine, Emilia Liana Falcone, Rahima Jamal, Me‐Linh Luong, Madéleine Durand, Stéphane Doucet, François Martin Carrier, Bryan Coburn, Lorenzo Del Sorbo, Sharon Walmsley, Sara Belga, Luke Y. C. Chen, Allison Mah, Theodore S. Steiner, Alissa Wright, J Hájek, Neill K. J. Adhikari, Nick Daneman, Kosar Khwaja, Jason Shahin, Carolina González, Rafael Silva, Marcelo Lindh, Gabriel Maluenda, Patricia Fernández, Maite Oyonarte, Martín Lasso, Alexandre Boyer, Didier Brönnimann, Hoang-Nam Bui, Charles Cazanave, H. Chaussade, Arnaud Desclaux, M. Ducours, Alexandre Duvignaud, Denis Malvy, Lisa J. Martin, D. Neau, Duc Thanh Nguyen, Thierry Pistone, Gaetane Soubrane-Wirth, Julie Leitao, Clotilde Allavena, Charlotte Biron, Sabelline Bouchez, Benjamin Gaborit, Antoine Grégoire, Paul Le Turnier, Anne-Sophie Lecompte, R. Lecomte, M. Lefèbvre, F. Raffi, David Boutoille, P Morineau, Romain Guéry, Emmanuel Chatelus, Nathalie Dumoussaud, Renaud Felten, Florina Luca, Bernard Goichot, Francis Schneider, Marie‐Caroline Taquet, Matthieu Groh, Mathilde Roumier, Mathilde Neuville, Antoine Bachelard, Valentina Isernia, F-Xavier Lescure, Bao-Chau Phung, A. Rachline, Aurélie Sautereau, D. Vallois, Yves Bleher, Delphine Boucher, Clémentine Coudon, J.-L. Esnault, Thomas Guimard, Sophie Leautez-Nainville, Dominique Merrien, Marine Morrier, Pauline Motte-Vincent, R. Gabeff, Hélène Leclerc, Céline Cozic, Romain Decours, Ronan Février, Gwenhaël Colin, Sophie Abgrall, Dorothée Vignes, R. Sterpu, Mira Kuellmar, Melanie Meersch, Raphael Weiß, Alexander Zarbock, Christiane Antony, Marc Moritz Berger, Thorsten Brenner, Christian Taube, Frank Herbstreit, Sebastian Dolff, Margarethe Konik, Karsten Schmidt, Markus Zettler, Oliver Witzke, Boris Boell, Jorge Garcia Borrega, Philipp Koehler, Thomas Zander, Fabian Dusse, Othman Al‐Sawaf, Philipp Köhler, Dennis A. Eichenauer, Matthias Kochanek, Alexander Shimabukuro‐Vornhagen, Sibylle C. Mellinghoff, Annika Y. Claßen, Jan‐Michel Heger, Charlotte Meyer‐Schwickerath, P. Liedgens, Katrin Heindel, Ana Belkin, Asaf Biber, Mayan Gilboa, Itzchak Levy, Vladislav Litachevsky, Galia Rahav, Anat Finesod Wiedner, Tal Zilberman‐Daniels, Yonatan Oster, Jacob Strahilevitz, Sigal Sviri, Elena Baldissera, Corrado Campochiaro, Giulio Giovanni Cavalli, Lorenzo Dagna, Giacomo De Luca, Emanuel Della‐Torre, Alessandro Tomelleri, Davide Bernasconi De Luca, Amedeo Capetti, Massimo Coen, Maria Vittoria Cossu, Massimo Galli, Andrea Giacomelli, G. Gubertini, Stefano Rusconi, Giulia Burastero, Margherita Digaetano, Giovanni Guaraldi, Marianna Meschiari, Cristina Mussini, Cinzia Puzzolante, Sara Volpi, Marina Aiello, Alarico Ariani, Alfredo Chetta, Annalisa Frizzelli, Andrea Ticinesi, Domenico Tuttolomondo, Stefano Aliberti, Francesco Blasi, Marta Francesca Di Pasquale, Sofia Misuraca, Tommaso Pilocane, Edoardo Simonetta, Alessio M. Aghelmo, Claudio Angelini, Enrico Brunetta, Giorgio Walter Canonica, Michele Ciccarelli, Sara Dal Farra, Maria De Santis, Sebastian Ferri, Marco Folci, Giacomo Maria Guidelli, Enrico Heffler, Ferdinando Loiacono, Giacomo Malipiero, Giovanni Paoletti, Rosa Pedale, Francesca Puggioni, Francesca Racca, Aurora Zumbo, Morihiko Satou, Tatyana Lisun, Д. Н. Проценко, Nikolay Rubtsov, Irina P. Beloglazova, Daria Fomina, Mariana Lysenko, Sofia A. Serdotetskova, Vitali Firstov, И. Г. Гордеев, Ilia Kokorin, Ksenia Komissarova, Н П Лапочкина, Е. Е. Лучинкина, Valentin Malimon, S. S. Mamedguseyinova, Ksenia Polubatonova, Natalia A. Suvorova, José Ramón Arribas, Alberto M. Borobia Perez, Juan Carlos Figueira, Marta Mora-Rillo, Concepcion Prados Sanchez, Javier Queiruga Parada, Francisco Arnalich, Maria Guerro Barrientos, Alejandro Bendala Estrada, María Eugenia García Leoni, Rita García‐Martínez, Ana María Moreno Collado, Patricia Muñoz García, Ana Torres do Rego, María Victoria Villalba García, Almudena Burrillo, Maricela Valerio Minero, Paloma Gijon Vidaurreta, Sonsoles Infante Herrero, Elena Velilla, Marina Machado, María Olmedo, Blanca Pinilla, Benito Almirante, Esperanza Cañas‐Ruano, S Medina, Alejandro Cortés Herrera, Vicenç Falcó Ferrer, Ricard Ferrer, X. Nuvials Casals, Paula Suanzes Diez, Pedro Rebollo Castro, Aina Oliver Caldes, Ana Gonzalez‐Cordón, Celia Cardozo, Lorena De la Mora Cañizo, Romina Pena López, Sandra Chamorro, Clara Crespillo‐Andújar, Rosa Escudero Sánchez, Jesús Fortün, Begoña Monge‐Maíllo, Francesca Norman, Matilde Sánchez‐Conde, Sergio Serrano‐Villar, Pilar Vizcarra
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
Bibliographic record
VenueThe Lancet Respiratory Medicine · 2021
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsHealth Sciences CentreSunnybrook Health Science Centre
FundersUniversity of Wisconsin-MadisonRegeneron PharmaceuticalsSanofi
KeywordsCoronavirus disease 2019 (COVID-19)PlaceboMedicineDouble blindSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakClinical trialEmergency medicineInternal medicineVirologyOutbreakAlternative medicinePathologyDisease
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.215
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.211
Threshold uncertainty score1.000
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.215 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.133
GPT teacher head0.475
Teacher spread0.342 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itQuick stats
Citations248
Published2021
Admission routes1
Has abstractno