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Global Impact of COVID-19 on Stroke Care and IV Thrombolysis
Raul G. Nogueira, Muhammad M. Qureshi, Mohamad Abdalkader, Sheila Cristina Ouriques Martins, Hiroshi Yamagami, Zhongming Qiu, Anvitha Sathya, Anna Członkowska, Georgios Tsivgoulis, Diana Aguiar de Sousa, Jelle Demeestere, Robert Mikulík, Peter Vanacker, James E. Siegler, Janika Kõrv, José Biller, Conrad W Liang, Navdeep Sangha, Alicia Zha, Alexandra L. Czap, Christine A Holmstedt, Tanya N. Turan, George Ntaios, Konark Malhotra, Ashis Tayal, Aaron Loochtan, Annemarei Ranta, Eva Mistry, Anne W. Alexandrov, David Huang, Shadi Yaghi, Eytan Raz, Sunil A. Sheth, Mahmoud Mohammaden, Michael Frankel, Eric Guemekane Bila Lamou, Hany Aref, Ahmed Elbassiouny, Farouk Hassan, Tarek Menecie, Wessam Mustafa, Hossam Shokri, Tamer Roushdy, Fred Stephen Sarfo, Tolulope Oyetunde Alabi, Babawale Arabambi, Ernest Nwazor, Taofiki Sunmonu, Kolawole Wahab, Joseph Yaria, Haytham Hussein Mohammed, Philip Adebayo, A. Riahi, Samia Ben Sassi, Lenon Gwaunza, Gift Ngwende, David Sahakyan, Aminur Rahman, Zhibing Ai, Fanghui Bai, Zhenhui Duan, Yonggang Hao, Wenguo Huang, Guangwen Li, Wei Li, Ganzhe Liu, Jun Luo, Xianjin Shang, Yi Sui, Ling Tian, Hongbin Wen, Bo Wu, Yuying Yan, Zhengzhou Yuan, Hao Zhang, Jun Zhang, Wenlong Zhao, Wenjie Zi, Thomas Leung, Chandril Chugh, Vikram Huded, Bindu Menon, Jeyaraj Pandian, PN Sylaja, Fritz Sumantri Usman, Mehdi Farhoudi, Elyar Sadeghi‐Hokmabadi, Anat Horev, Anna Reznik, Rotem Sivan Hoffmann, Nobuyuki Ohara, Nobuyuki Sakai, Daisuke Watanabe, Ryoo Yamamoto, Ryosuke Doijiri, Naoki Tokuda, Takehiro Yamada, Tadashi Terasaki, Yukako Yazawa, Takeshi Uwatoko, Tomohisa Dembo, Hisao Shimizu, Yuri Sugiura, Fumio Miyashita, Hiroki Fukuda, Kosuke Miyake, Junsuke Shimbo, Yusuke Sugimura, Yoshiki Yagita, Yohei Takenobu, Yuji Matsumaru, Satoshi Yamada, Ryuhei Kono, Takuya Kanamaru, Hidekazu Yamazaki, Manabu Sakaguchi, Kenichi Todo, Nobuaki Yamamoto, Kazutaka Sonoda, Tomoko Yoshida, Hiroyuki Hashimoto, Ichiro NAKAHARA, Аida Kondybayeva, Kamila Faizullina, Saltanat Kamenova, Murat Zhanuzakov, Jang‐Hyun Baek, Yang‐Ha Hwang, Jin Soo Lee, Si Baek Lee, Jusun Moon, Hyungjong Park, Jung Hwa Seo, Kwon–Duk Seo, Sung‐Il Sohn, Chang Jun Young, Rechdi Ahdab, Wan Asyraf Wan Zaidi, Zariah Abdul Aziz, Hamidon Basri, Law Wan Chung, Aznita Binti Ibrahim, Khairul Azmi Ibrahim, Irene Looi, Wee Yong Tan, Wan Yahya Nafisah, Stanislav Groppa, Pavel Leahu, Amal Al Hashmi, Yahia Imam, Naveed Akhtar, Maria Carissa Pineda-Franks, Christian Oliver, Д В Кандыба, Adel Alhazzani, Hosam Al-Jehani, Carol Huilian Tham, Marlie Jane Mamauag, Narayanaswamy Venketasubramanian, Chih‐Hao Chen, Sung‐Chun Tang, Anchalee Churojana, Eşref Akıl, Özlem Aykaç, Atilla Özcan Özdemi̇r, Semih Giray, Syed Hussain, Seby John, Huynh Le Vu, Anh Đức Trần, Huy Hoàng Nguyễn, Thong Nhu Pham, Thang Huy Nguyen, Trung Quoc Nguyen, Thomas Gattringer, Christian Enzinger, Monika Killer‐Oberpfalzer, Flavio Bellante, Sofie De Blauwe, Geert Vanhooren, Sylvie De Raedt, Anne Dusart, Robin Lemmens, Noémie Ligot, Matthieu Pierre Rutgers, Laetitia Yperzeele, Filip Alexiev, Teodora Sakelarova, Marina Roje Bedeković, Hrvoje Budinčević, Igor Cindrić, Zlatko Hucika, David Ozretić, Majda Seferovic Saric, František Pfeifer, Igor Karpowic, David Černík, Martin Šrámek, Miroslav Škoda, Helena Hlaváčová, Lukáš Klečka, Martin Koutny, Daniel Václavík, Ondřej Škoda, Jan Fiksa, Katerina Hanelova, Miroslava Nevšímalová, Robert Rezek, Petr Procházka, Gabriela Krejstova, Jiří Neumann, Marta Vachová, Henryk Brzezanski, David Hlinovský, Dusan Tenora, R Jura, Lubomír Jurák, Jan Novák, Aleš Novák, Zdenek Topinka, Petr Fibrich, Helena Sobolová, Ondřej Volný, Nicolas Drenck, Helle K. Iversen, Claus Z. Simonsen, Thomas Truelsen, Troels Wienecke, Riina Vibo, Katrin Gross‐Paju, Katrin Antsov, François Caparros, Charlotte Cordonnier, Maria Dan, Jean‐Marc Faucheux, Laura Mechtouff, Ömer EKER, É. Lesaine, Basile Ondzé, Roxane Peres, Fernando Pico, Michel Piotin, Raoul Pop, François Rouanet, Tatuli Gubeladze, Mirza Khinikadze, Nino Lobjanidze, Alexander Tsiskaridze, Simon Nagel, Peter A. Ringleb, Michael Rosenkranz, Holger Schmidt, Annahita Sedghi, Timo Siepmann, Kristina Szabo, Götz Thomalla, Lina Palaiodimou, Dimitrios Sagris, Odysseas Kargiotis, Péter Klivènyi, László Szapáry, Gábor Tárkányi, Alessandro Adami, Fabio Bandini, Paolo Calabresi, Giovanni Frisullo, Leonardo Renieri, Davide Sangalli, Anne Pirson, Maarten Uyttenboogaart, Ido R. van den Wijngaard, Espen Saxhaug Kristoffersen, Waldemar Brola, Małgorzata Fudala, Ewa Horoch-Łyszczarek, Michał Karliński, Radosław Kaźmierski, Paweł Kram, Marcin Rogoziewicz, Rafał Kaczorowski, Piotr Luchowski, Halina Sienkiewicz‐Jarosz, Piotr Sobolewski, Waldemar Fryze, Anna Wiśniewska, M Wiszniewska, Patrícia Ferreira, Paulo Ferreira, Luísa Fonseca, João Pedro Marto, Teresa M. V. D. Pinho e Melo, Ana Paiva Nunes, Miguel Rodrigues, Vítor Tedim Cruz, Cristian Falup‐Pecurariu, Georgi Krastev, Miroslav Mako, María Alonso de Leciñana, Juan F. Arenillas, Óscar Ayo‐Martín, Antonio Culebras, Exuperio Díez‐Tejedor, Joan Montaner, Soledad Pérez-Sánchez, Miguel Ángel Tola-Arribas, Alejandro Rodríguez Vásquez, Michael Mayza, Gianmarco Bernava, Alex Brehm, Paolo Machi, Urs Fischer, Jan Gralla, Patrik Michel, Marios‐Nikos Psychogios, Davide Strambo, Soma Banerjee, Kailash Krishnan, Joseph Kwan, Asif Butt, Luciana Catanese, Andrew M. Demchuk, Thalia S. Field, Jennifer Haynes, Michael D. Hill, Houman Khosravani, Ariane Mackey, Aleksandra Pikula, Gustavo Saposnik, Courtney Anne Scott, Ashkan Shoamanesh, Ashfaq Shuaib, Samuel Yip, Miguel A. Barboza, José Domingo Barrientos, Ligia Ibeth Portillo Rivera, Fernando Góngora‐Rivera, Nelson Novarro, Anmylene Blanco, Michael Abraham, Diana Alsbrook, Dorothea Altschul, Anthony J. Alvarado-Ortiz, Ivo Bach, Aamir Badruddin, Nobl Barazangi, Charmaine Brereton, Alicia C. Castonguay, Seemant Chaturvedi, Saqib Chaudry, Hana Choe, Jae Hyung Choi, Sushrut Dharmadhikari, Kinjal Desai, Thomas Devlin, Vinodh T Doss, Randall C. Edgell, Mark R. Etherton, Mudassir Farooqui, Don Frei, Dheeraj Gandhi, Mikayel Grigoryan, Rishi Gupta, Ameer E Hassan, Johanna Helenius, Artem Kaliaev, Ritesh Kaushal, Priyank Khandelwal, Ayaz Khawaja, Naïm Khoury, Benny S. Kim, Dawn Kleindorfer, Feliks Koyfman, V Lee, Lester Y. Leung, Guillermo Linares, Italo Linfante, Helmi L. Lutsep, Lisa Macdougall, Shailesh Male, Amer M. Malik, Hesham Masoud, Brijesh Mehta, Jiangyong Min, Manoj Mittal, Jane G. Morris, Sumeet Multani, Fadi Nahab, Krishna Nalleballe, Claude Nguyen, Roberta Novakovic‐White, Santiago Ortega‐Gutiérrez, Rahul Rahangdale, Pankajavalli Ramakrishnan, José R. Romero, Natalia S. Rost, Aaron Rothstein, Sean Ruland, Ruchir Shah, Malveeka Sharma, Brian Silver, Marc Simmons, Abhishek Singh, Amy Starosciak, Sheryl Strasser, Viktor Szeder, Mohamed Teleb, Jenny P. Tsai, Barbara Voetsch, Oscar Balaguera, Virginia Pujol Lereis, Adriana Luraschi, Marcele Schettini Almeida, Fabrício Bruno Cardoso, Adriana Bastos Conforto, Leonardo Deus-Silva, Luidia Varrone Giacomini, Fabrício Oliveira Lima, Alexandre Luiz Longo, Pedro Magalhães, Rodrigo Targa Martins, Francisco Mont’Alverne, Daissy Liliana Mora Cuervo, Letícia C. Rebello, Lenise Valler, Viviane Flumignan Zétola, Pablo M. Lavados, Víctor Navia, Verónica V. Olavarría, Juan Manuel Toro, Hernán Bayona, Ángel Corredor, Carlos Eduardo Rivera Ordoñez, Diana Katherine Mantilla Barbosa, Osvaldo Lara, Mauricio R. Patiño, Luis Escobar, Donoband Edson Dejesus Melgarejo Fariña, Analia Cardozo Villamayor, Adolfo Javier Zelaya Zarza, Danny M. Barrientos-Imán, Liliana Rodríguez Kadota, Bruce Campbell, Graeme J. Hankey, Casey Hair, Timothy Kleinig, Alice Ma, Rodrigo Tomazini Martins, Ramesh Sahathevan, Vincent Thijs, Daniel E. Salazar, Teddy Y. Wu, Diogo C Haussen, David S. Liebeskind, Dileep R. Yavagal, Tudor G. Jovin, Osama O. Zaidat, Thanh N. Nguyen
Bibliographic record
VenueNeurology · 2021
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 and healthcare impacts
Canadian institutionsnot available
FundersNational Institute of Neurological Disorders and StrokeUniversitätsklinikum Hamburg-EppendorfChangi General HospitalSanofi GenzymeUniversity of North Carolina at Chapel HillUniversité de Versailles Saint-Quentin-en-YvelinesLeonard M. Miller School of MedicineBispebjerg HospitalNYU Grossman School of MedicineSzegedi TudományegyetemSouthwest Medical UniversityClínica Alemana de SantiagoSjællands UniversitetshospitalKwame Nkrumah University of Science and TechnologyParacelsus Medizinische PrivatuniversitätMassachusetts General HospitalLékařská fakulta, Masarykova univerzitaCreighton UniversityUniversity of TokushimaUniversity of ThessalyGaziantep ÜniversitesiEuropean CommissionUniversity of TabrizOhio State UniversityUniversity of Arkansas for Medical SciencesCentre Hospitalier Universitaire VaudoisUniversity of MiamiNational Science FoundationUniversité de LausanneEskişehir Osmangazi ÜniversitesiAnna UniversityDicle ÜniversitesiImam Abdulrahman Bin Faisal UniversityFujian Medical UniversityUniversidad de ValladolidHospices Civils de LyonUniversity of NottinghamUniversitetet i OsloCollege of Engineering, Michigan State UniversityTartu ÜlikoolServierMaastricht Universitair Medisch CentrumZhejiang UniversityTabriz University of Medical SciencesFleniSchweizerische HerzstiftungNovo NordiskMahidol UniversityKarolinska InstitutetFaculty of Medicine Siriraj Hospital, Mahidol UniversitySanofiEisaiUniversity of TsukubaShandong First Medical UniversityBundesministerium für GesundheitInstituto de Salud Carlos IIIStrykerQingdao UniversityKing Saud UniversityUniversitätsmedizin GöttingenDaiichi-SankyoCairo UniversityAin Shams UniversityUniversiteit MaastrichtMinistry of Education, Culture, Sports, Science and TechnologyNational Taiwan UniversityInstitut National de la Santé et de la Recherche MédicaleUniwersytet Jana Kochanowskiego w KielcachKowa CompanyUniversity of TorontoGenentechUniversity of AlbertaImperial College LondonAstraZenecaMansoura UniversityHaaglanden Medisch CentrumAustralian GovernmentUniversity of WashingtonPfizerUniversity of Texas Rio Grande ValleyEmory UniversitySutter HealthSichuan UniversityImperial College Healthcare NHS TrustVanderbilt University Medical CenterFujita Health UniversityNottingham University Hospitals NHS TrustMcMaster UniversityDaiichi Sankyo EuropeWannan Medical CollegeHotchkiss Brain Institute, University of CalgaryUniversity of OtagoUniversity of Texas Southwestern Medical CenterRigshospitaletAarhus UniversitetshospitalSchool of Medicine, Boston UniversityState University of New YorkTeva Pharmaceutical IndustriesBristol-Myers SquibbSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungWest China Hospital, Sichuan UniversityVanderbilt UniversityYork UniversityCleveland ClinicUniversitair Medisch Centrum GroningenMasarykova UniverzitaBiogenTufts Medical CenterMichigan State UniversityKarl-Franzens-Universität GrazUniversity of BernNational Taiwan University HospitalAmgenKawasaki Medical SchoolMedizinische Universität GrazNarodowe Centrum Badań i RozwojuUniversity of PennsylvaniaAkershus UniversitetssykehusShionogiHamad Medical CorporationNational Institutes of HealthChinese University of Hong KongSir Run Run Shaw HospitalAstellas PharmaUniwersytet Medyczny w LublinieAarhus UniversitetJapan Society for the Promotion of ScienceUniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
KeywordsCoronavirus disease 2019 (COVID-19)Thrombolysis2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Stroke (engine)MedicinePandemicBetacoronavirusEmergency medicineVirologyMedical emergencyInternal medicineOutbreakEngineeringMyocardial infarction
Abstract
OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. RESULTS: < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. CONCLUSIONS: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.017
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.046
GPT teacher head0.414
Teacher spread0.368 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations154
Published2021
Admission routes1
Has abstractyes