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Learning and Memory in Fruit Flies and Nematodes

2021· other· en· W3136498180 on OpenAlexaff
Desta R Rabin, Catharine H. Rankin

Bibliographic record

VenueEncyclopedia of Life Sciences · 2021
Typeother
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsDrosophila melanogasterMelanogasterBiologyCaenorhabditis elegansAssociative learningModel organismDrosophila (subgenus)Key (lock)GeneGeneticsCognitive scienceNeurosciencePsychologyEcology

Abstract

fetched live from OpenAlex

Learning is the acquisition of new, and memory is when the expression of that knowledge changes behaviour. Drosophila melanogaster and Caenorhabditis elegans have been essential to research that explores the underlying mechanisms of learning and memory. These two model organisms provide unique opportunities for research, as they are easily managed, have short lifespans and reproduce many offspring very quickly. Both of these organisms are susceptible to forward and reverse mutagenesis techniques, and the experimental paradigms that are currently in use to study their behaviour are straightforward and well-established protocols. Many genes that are conserved in humans have become targets of interest for learning and memory researchers through experiments on C. elegans and D. melanogaster , and now the roles of individual genes are being linked together to explain the complex networks that mediate different forms of learning and memory. Key Concepts Learning is essential for living organisms, and learning and memory mechanisms are conserved across phylogeny. Genetic, molecular and physiological activities are crucial for learning and memory. C. elegans and D. melanogaster are established model organisms to study learning. C. elegans and D. melanogaster are both capable of nonassociative and associative forms of learning. C. elegans and D. melanogaster both can show short- and long-term memory. Genes that are central to learning and memory are often the same in both model organisms.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.009
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0090.005

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.251
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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