Association between psoriasis and dementia: A systematic review
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Risk factors for dementia include genetic factors, aging, environmental factors, certain diseases, and unhealthy lifestyle; most types of dementia share a common chronic systemic inflammatory phenotype. Psoriasis is also considered to be a chronic systemic inflammatory disease. It has been suggested that psoriasis may also contribute to the risk of dementia. The aim of this study was to systematically review the literature on the association between psoriasis and dementia. Articles were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched the PubMed and Web of Science databases to identify articles published in peer-reviewed journals and studying the association between psoriasis and dementia. Studies meeting the inclusion criteria were reviewed. We used the Newcastle–Ottawa Scale to assess the quality of each study. After applying the inclusion and exclusion criteria, we included 8 studies for review, 3 of which were found to present a higher risk of bias. Six of the 8 studies supported the hypothesis that prior diagnosis of psoriasis increases the risk of dementia; one study including only a few cases reported that psoriasis decreased the risk of dementia, and one study including relatively young patients found no significant association between psoriasis and the risk of dementia. Most studies included in this review supported the hypothesis that psoriasis constitutes a risk factor for dementia. However, well-designed stratified cohort studies assessing both psoriasis severity and treatment status are still required to determine the real effect of psoriasis on the risk of dementia and its subtypes. Entre los factores de riesgo de la demencia se incluyen algunas características genéticas, el envejecimiento, factores medioambientales, determinadas enfermedades y estilos de vida poco saludables. La mayoría de los tipos de demencia comparten un fenotipo de carácter inflamatorio, sistémico y crónico. La psoriasis también se considera una enfermedad inflamatoria, sistémica y crónica. Se ha especulado que la psoriasis podría aumentar el riesgo de demencia. El objetivo de este estudio es realizar una revisión sistemática de la literatura disponible sobre la posible asociación entre la psoriasis y el desarrollo de demencia. Seleccionamos los artículos siguiendo las directrices de la declaración Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), utilizando las bases de datos PubMed y Web of Science para localizar artículos publicados en revistas científicas que analizaran la asociación entre psoriasis y demencia. Incluimos en nuestra revisión los artículos que cumplían los criterios de inclusión. Para valorar la calidad de los estudios, usamos la escala Newcastle-Ottawa. Tras aplicar los criterios de inclusión y exclusión, seleccionamos 8 estudios, de los cuales 3 presentaban un mayor riesgo de sesgo. Seis de los 8 estudios postulan la hipótesis de que el diagnóstico de psoriasis aumenta el riesgo de desarrollar demencia posteriormente. Por otro lado, un estudio que incluía solo algunos casos describe que la psoriasis disminuye el riesgo de demencia y un estudio con pacientes relativamente jóvenes no encontró asociación significativa entre la psoriasis y el riesgo de desarrollar demencia. La mayoría de los estudios incluidos en esta revisión apoyan la hipótesis de que la psoriasis representa un factor de riesgo de desarrollar demencia. Sin embargo, se necesitan más estudios de cohortes con un diseño adecuado que analicen tanto la gravedad de la psoriasis como el estado del tratamiento para determinar el efecto real de la psoriasis sobre el riesgo de desarrollar demencia y sus subtipos.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.004 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it