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Record W313784884 · doi:10.1038/mt.2009.86

Oncolytic Viruses: Time to Compare, Contrast, and Combine?

2009· article· en· W313784884 on OpenAlexaboutno aff
Hardev Pandha, Alan Melcher, Kevin J. Harrington, Richard G. Vile

Bibliographic record

VenueMolecular Therapy · 2009
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicVirus-based gene therapy research
Canadian institutionsnot available
Fundersnot available
KeywordsOncolytic virusClinical trialVirotherapyMedicineComputer sciencePsychologyVirusVirologyPathology

Abstract

fetched live from OpenAlex

Creeping cautiously at 15 mph into the teeth of a driving snowstorm along a dark, deserted Canadian highway at 4 am, returning from the 5th International Meeting on Replicating Oncolytic Virus Therapeutics, provided an ideal opportunity for some thoughtful reflection. To avoid contemplating the possibility of our imminent demise—perhaps by plunging off the mountain or being mowed down by a truck—we used the time to reflect on the content of the meeting and to formulate our ideas about the current state of the field.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.115
metaresearch head score (Gemma)0.176
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.115
Threshold uncertainty score0.608

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.1150.176
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0060.003
Bibliometrics0.0040.003
Science and technology studies0.0030.010
Scholarly communication0.0220.050
Open science0.0050.011
Research integrity0.0110.024
Insufficient payload (model declined to judge)0.0250.014

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.301
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations10
Published2009
Admission routes1
Has abstractyes

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