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Record W3138574248 · doi:10.1016/s2213-2600(20)30532-4

Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

2021· article· en· W3138574248 on OpenAlexaff
Marius M. Hoeper, Hikmet Al‐Hiti, Raymond L. Benza, Sung‐A Chang, Paul A. Corris, J. Simon R. Gibbs, Ekkehard Grünig, Pavel Jansa, James R. Klinger, David Langleben, Vallerie V. McLaughlin, G. Meyer, Jaquelina Sonoe Ota Arakaki, Andrew J. Peacock, Tomás Pulido, Stephan Rosenkranz, Carmine Dario Vizza, Anton Vonk Noordegraaf, R.J. White, Mikyung Chang, Frank Kleinjung, Christian Meier, Karen Paraschin, Hossein Ardeschir Ghofrani, Gérald Simonneau, Horst Olschewski, Marion Delcroix, Marina Andrade‐Lima, R de Amorim Corrêac, F Figueiredo Campos, Jaquelina O. Arakaki, Rogério Souza, Søren Mellemkjær, Fabrice Bauer, David Montani, Daniel Drömann, Michael Halank, Matthias Held, Hans Klose, Nikolaus Kneidinger, Hanno Leuchte, Christian Opitz, Heinrike Wilkens, Hubert Wirtz, Haralampos Karvounis, Georgia Pitsiou, Stylianos E. Orfanos, Michael D’Alto, Stefano Ghio, CD Vizza, Patrizio Vitulo, T. Nakayama, Hisataka Maki, Shunsuke Tatebe, Manuel Ibarra, Arie P.J. van Dijk, Tomasz Roleder, G. Castro, MJ Loureiro, Susana Robalo-Martins, Joan Albert Barberà, GM Perez-Penate, Antonio Román, C-H. Hsu, Erhan Atahan, NG Okumus, Zeynep Pınar Önen, Chang Hj, Jin Sun Lee, JG Coghlan, PA Corris, Colin Church, Robin Condliffe, AJ Peacock, Stephen J. Wort, Roblee P. Allen, Samuel A. Allen, Rana Awdish, RL Benza, Shilpa A. DeSouza, Jeremy Feldman, Shilpa Johri, JR Klinger, Daniel Layish, John McConnell, VV McLaughlin, Christina Migliore, Franck Rahaghi, Franz Rischard, Ivan M. Robbins, Lewis Satterwhite, Trushil Shah, Roxana Sulica

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2021
Typearticle
Languageen
FieldMedicine
TopicPulmonary Hypertension Research and Treatments
Canadian institutionsMcGill UniversityJewish General Hospital
FundersBayer
KeywordsRiociguatMedicinecGMP-specific phosphodiesterase type 5Chronic thromboembolic pulmonary hypertensionOpen labelPulmonary hypertensionRescue therapySildenafilInternal medicineRandomized controlled trialCardiologyIntensive care medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.029

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0050.004
Bibliometrics0.0000.000
Science and technology studies0.0000.002
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.068
GPT teacher head0.324
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations161
Published2021
Admission routes1
Has abstractno

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