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Record W3138574248 · doi:10.1016/s2213-2600(20)30532-4

Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial

2021· article· en· W3138574248 on OpenAlexaff
Marius M. Hoeper, Hikmet Al‐Hiti, Raymond L. Benza, Sung‐A Chang, Paul A. Corris, J. Simon R. Gibbs, Ekkehard Grünig, Pavel Jansa, James R. Klinger, David Langleben, Vallerie V. McLaughlin, G. Meyer, Jaquelina Sonoe Ota Arakaki, Andrew J. Peacock, Tomás Pulido, Stephan Rosenkranz, Carmine Dario Vizza, Anton Vonk Noordegraaf, R.J. White, Mikyung Chang, Frank Kleinjung, Christian Meier, Karen Paraschin, Hossein Ardeschir Ghofrani, Gérald Simonneau, Horst Olschewski, Marion Delcroix, Marina Andrade‐Lima, R de Amorim Corrêac, F Figueiredo Campos, Jaquelina O. Arakaki, Rogério Souza, Søren Mellemkjær, Fabrice Bauer, David Montani, Daniel Drömann, Michael Halank, Matthias Held, Hans Klose, Nikolaus Kneidinger, Hanno Leuchte, Christian Opitz, Heinrike Wilkens, Hubert Wirtz, Haralampos Karvounis, Georgia Pitsiou, Stylianos E. Orfanos, Michael D’Alto, Stefano Ghio, CD Vizza, Patrizio Vitulo, T. Nakayama, Hisataka Maki, Shunsuke Tatebe, Manuel Ibarra, Arie P.J. van Dijk, Tomasz Roleder, G. Castro, MJ Loureiro, Susana Robalo-Martins, Joan Albert Barberà, GM Perez-Penate, Antonio Román, C-H. Hsu, Erhan Atahan, NG Okumus, Zeynep Pınar Önen, Chang Hj, Jin Sun Lee, JG Coghlan, PA Corris, Colin Church, Robin Condliffe, AJ Peacock, Stephen J. Wort, Roblee P. Allen, Samuel A. Allen, Rana Awdish, RL Benza, Shilpa A. DeSouza, Jeremy Feldman, Shilpa Johri, JR Klinger, Daniel Layish, John McConnell, VV McLaughlin, Christina Migliore, Franck Rahaghi, Franz Rischard, Ivan M. Robbins, Lewis Satterwhite, Trushil Shah, Roxana Sulica

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2021
Typearticle
Languageen
FieldMedicine
TopicPulmonary Hypertension Research and Treatments
Canadian institutionsMcGill UniversityJewish General Hospital
FundersBayer
KeywordsRiociguatMedicinecGMP-specific phosphodiesterase type 5Chronic thromboembolic pulmonary hypertensionOpen labelPulmonary hypertensionRescue therapySildenafilInternal medicineRandomized controlled trialCardiologyIntensive care medicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.019
Threshold uncertainty score0.873

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.068
GPT teacher head0.324
Teacher spread0.255 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations161
Published2021
Admission routes1
Has abstractno

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