MétaCan
Menu
Back to cohort
Record W3138817412 · doi:10.1038/s41587-021-00860-4

Ultra-fast proteomics with Scanning SWATH

2021· article· en· W3138817412 on OpenAlexaff
Christoph B. Messner, Vadim Demichev, Nic Bloomfield, Jason Yu, Matthew White, Marco Kreidl, Anna-Sophia Egger, Anja Freiwald, Gordana Ivosev, Fras Wasim, Aleksej Zelezniak, Linda Jürgens, Norbert Suttorp, Leif Erik Sander, Florian Kurth, Kathryn S. Lilley, Michael Mülleder, Stephen Tate, Markus Ralser

Bibliographic record

VenueNature Biotechnology · 2021
Typearticle
Languageen
FieldChemistry
TopicAdvanced Proteomics Techniques and Applications
Canadian institutionsSpinal Cord Injury BC
FundersBiotechnology and Biological Sciences Research CouncilMedical Research CouncilBerlin University AllianceBerlin Institute of HealthUniversität InnsbruckScience for Life LaboratoryBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchDeutsche ForschungsgemeinschaftUK Research and InnovationWellcome TrustFrancis Crick InstituteCancer Research UKResearch Councils UKLifeArc
KeywordsProteomeProteomicsMass spectrometryBiomarker discoveryTandem mass spectrometryBiomarkerChromatographyChemistryComputational biologyBiologyBiochemistry

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.008
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0080.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.246
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations327
Published2021
Admission routes1
Has abstractno

Explore more

Same venueNature BiotechnologySame topicAdvanced Proteomics Techniques and ApplicationsFrench-language works237,207