Automation of single cell surgery in real-time using a vision-based control system
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Micromanipulation of biological cells is a challenging task that requires levels of precision and repeatability which are difficult to achieve by most human operators. Automation of these processes presents an alternative approach which is capable of high precision task execution and much higher throughput, yet with its own limitations. In this paper, we propose automation methods for the image-based visual servo control feedback and tracking of both blastomeres' motion and the motion of micromanipulators, in real-time, for blastomere microinjection. An automation procedure is developed for the microinjection or blastomere biopsy of an early stage embryonic cell. These steps involve blastomere z-stack image acquisition, blastomere feature detection (x, y, z) location, and real-time image-based visual servo control of micropipettes to hold and immobilise the embryo while a micropipette injects or biopsies the blastomere. Experimental results demonstrate acceptable precision levels while performing automation procedure in real-time.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it