Abstract P339: Evaluating Ga68 Regional Distribution as a New Pet Tracerfor Diagnosis Cerebral Amyloid Angiopathy
Bibliographic record
Abstract
Introduction: The deposition of β-amyloid in cerebral vessels is an important sign of CAA. Recently, the 68Ga-P14-032 has been used in animal research. It has the ability to selectively bind a β on the cerebral vessel wall, and may become a tracer for CAA. hypothesis: We aimed to investigate the distribution of [ 68 Ga]Ga-P14-032, a novel PET ligand that binds to vascular amyloid, in patients diagnosed clinically with probable cerebral amyloid angiopathy (CAA). Methods: This longitudinal cohort study of 7 subjects (2 probable CAA patients, 2 AD patients, 3 normal subjects) recruited from clinics in China. All participants were aged at least 55 years with underwent [ 68 Ga]Ga-P14-032 PET/CT and PET/MR, a Montreal Cognitive Assessment (Moca) score on initial assessment. The brain PET/CT and PET/MR scans assessed through quantitative analysis. The mean cortical standardized uptake value ratio (SUVr) was calculated using cerebellum as reference. The cortex and white matter were segmented with ITK-Snap based on a T1-weighed image as the mask, leaving the scalp and the blood vessels out of the regions of interest. The corresponding PET volumes were extracted according to the masks obtained on MR and were fused with the MR images, using a MATLAB script. The images were read and interpreted by 2 doctors in nuclear medicine.Plasma levels of total-tau, amyloid-b40 and amyloid-b42 were measured by a single molecule array (Simoa) SR-X analyzer (Quanterix). Results: Positive expression can be seen in the pathological part of microvascular in 2 CAA patients of whom had an ICH. No significant signal was seen in AD subjects or controls. Plasma levels of total-tau, amyloid-b40 and amyloid-b42 were not different among the groups. Conclusions: Our results provide early evidence that the [68Ga]Ga-P14-032 PET probe binds preferentially to vascular amyloid, and may be a useful tracer to diagnostic of CAA. The PET marker was more sensitive to group differences than plasma assays of tau and amyloid.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".