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Record W3139439448 · doi:10.1093/neuonc/noab067

The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

2021· article· en· W3139439448 on OpenAlexafffund
Fabio Girardi, Brian Rous, Charles Stiller, Gemma Gatta, Naomi Fersht, Hans H. Storm, Jéssica Rodrigues, C. Herrmann, Rafael Marcos‐Gragera, Rafael Peris‐Bonet, М. Yu. Valkov, Hannah K Weir, Ryan Woods, Hui You, Patricia Cueva, Prithwish De, V Di Carlo, Tom Børge Johannesen, Carlos Anselmo Lima, Charles F. Lynch, Michel P. Coleman, Claudia Allemani, S. Bouzbid, M Hamdi-Chérif, Zoubida Zaidi, Kaouel Meguenni, D. Regagba, Saray Mormeneo Bayo, T Cheick Bougadari, S S Manraj, Karima Bendahhou, A Ladipo, Olufemi J. Ogunbiyi, Thendo Ramaliba, Nontuthuzelo Somdyala, M A Chaplin, Florencia Moreno, G.H. Calabrano, S.B. Espinola, B Carballo Quintero, R Fita, W.D. Laspada, S.G. Ibañez, A Mafra da Costa, P.C.F. De Souza, C. Laporte, María Paula Curado, José Carlos de Oliveira, C.L.A. Veneziano, Donaldo Botelho Veneziano, M R D O Latorre, Luana Fiengo Tanaka, Marise Souto Rebelo, M O Santos, Gulnar Azevedo e Silva, J.C. Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D.A. Herrmann, S Torres Vargas, Víctor Herrera, Claudia Uribe, Luis Eduardo Bravo, Luz Stella García, Nelson Enrique Arias-Ortiz, D Morantes, Daniel Jurado, María Clara Yépez Chamorro, Sandra Delgado, Melissa Ramirez, Y H Galán Alvarez, Priscila Torres, F Martínez-Reyes, L. Jaramillo, R. Quinto, J Castillo, M Mendoza, J.G. Yépez, Bernard Bhakkan, Jacqueline Deloumeaux, Clarisse Joachim, Jonathan Macni, R Carrillo, Rebeca Rivera-Gómez, P Pérez, Ebert Poquioma, Guillermo Tortolero‐Luna, Diego Zavala, R. Alonso, Enrique Barrios, Angela Eckstrand, C Nikiforuk, Glen Noonan, Donna Turner, Eshwar Kumar, B Zhang, F.R. McCrate, S. Ryan, M Macintyre, Nathalie Saint‐Jacques, A Anam, P De, C A McClure, K.A. Vriends, Christine Bertrand, Jean Latreille, Serena Kozie, H. Stuart-Panko, T Freeman, J T George, Rosa M. Avila, David K. O’Brien, A Holt, Lyn Almon, Sandy Kwong, Cyllene R. Morris, R Rycroft, Lloyd Mueller, Cathryn Phillips, Heather M. Brown, B Cromartie, Ann G. Schwartz, Fawn D. Vigneau, G M Levin, Brad Wohler, Rana Bayakly, Kevin C. Ward, Scarlett Lin Gomez, Meg McKinley, Rosemary D. Cress, M D Green, K Miyagi, Christopher J. Johnson, Laura Ruppert, Suzanne Bentler, Martin Charlton, Bin Huang, T. C. Tucker, Dennis Deapen, L Liu, Mei‐Chin Hsieh, Xiao‐Cheng Wu, Molly Schwenn, Kimberly J. Stern, S T Gershman, Richard Knowlton, Georgetta Alverson, Timothy D. Weaver, Sally Bushhouse, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, Michelle M. Hood, J Roberts-Johnson, Bruce L. Riddle, Judy R. Rees, Karen Pawlish, Antoinette M. Stroup, Cas Key, Charles L. Wiggins, Amy R. Kahn, Maria J. Schymura, S Radhakrishnan, Chandrika Rao, L K Giljahn, R M Slocumb, A Feld, K G Aird, T Beran, J J Rubertone, S J Slack, Jae Hwan Oh, T A Janes, Stephen M. Schwartz, S Chiodini, Deborah Hurley, Martin Whiteside, Saroj Rai, Melanie Williams, Kim Herget, Carol Sweeney, Alison Johnson, M B Keitheri Cheteri, Patti Migliore Santiago, S E Blankenship, S Farley, R.R. Borchers, R Malicki, J Espinoza, Joseph Grandpre, H.K. Weir, Reda Wilson, B. K. Edwards, A Mariotto, Ning Wang, Lei Yang, J S Chen, Yanjun Zhou, Yufang He, G H Song, Xiaoping Gu, Dan Mei, Huijuan Mu, H M Ge, T H Wu, Y Y Li, Di Zhao, J H Zhang, F D Zhu, Y L Yang, C X Jiang, J Wang, Q L Li, H Yi, Xin Zhou, Jie Dong, W Li, F X Fu, S Z Liu, Jianguo Chen, Jian Zhu, Y H Li, Yuqiang Lu, Min Fan, Suqin Huang, G P Guo, Hua Zhao-lai, Kuangrong Wei, W-Q Chen, Wenqiang Wei, Hongmei Zeng, A Demetriou, W.K. Mang, K.C. Ngan, A.C. Kataki, Manigreeva Krishnatreya, P A Jayalekshmi, P. Sebastian, Preethi Sara George, A. Mathew, A Nandakumar, Reza Malekzadeh, Gholamreza Roshandel, Lital Keinan-Boker, Barbara Silverman, Yuriko N. Koyanagi, Hidemi Ito, M Sato, F Tobori, I Nakata, N Teramoto, Masaya Hattori, Yasuharu Kaizaki, Fumitaka Moki, Hiromi Sugiyama, Mai Utada, M Nishimura, Keisuke Yoshida, K Kurosawa, Y Nemoto, Hiroto Narimatsu, Masahiko Sakaguchi, Seiki Kanemura, Michiko Naito, Rintaro Narisawa, Isao Miyashiro, Kayo Nakata, Akihiro Maeda, S Sato, Izumi Oki, Noriyoshi Fukushima, Akiko Shibata, K Iwasa, Chikako Ono, Tomohiro Matsuda, Omar Nimri, Kyu‐Won Jung, Young‐Joo Won, Eiman Alawadhi, A Elbasmi, Azizah Ab Manan, Farzaana Adam, E Nansalmaa, Undarmaa Tudev, Chimedsuren Оchir, A M Al Khater, M.M. El Mistiri, G H Lim, Yik Ying Teo, Chun‐Ju Chiang, W C Lee, R Buasom, Suleeporn Sangrajrang, Krittika Suwanrungruang, Patravoot Vatanasapt, Karnchana Daoprasert, D Pongnikorn, Atit Leklob, S Sangkitipaiboon, Sarayut Lucien Geater, Hutcha Sriplung, O Ceylan, İskender Kög, Oya Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, Sultan Eser, Cankut Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, Monika Hackl, A. Zborovskaya, Olga Aleinikova, K. Henau, Liesbet Van Eycken, Z. Valerianova, Mariya Yordanova, Mario Šekerija, Ladislav Dušek, Miroslav Zvolský, Lina Steinrud Mørch, Charlotte Wessel Skovlund, Kaire Innos, Margit Mägi, Nea Malila, Karri Seppä, Jérémie Jegu, Michel Velten, Édouard Cornet, Xavier Troussard, Anne‐Marie Bouvier, A.V. Guizard, Véronique Bouvier, Guy Launoy, P. Arveux, Marc Maynadié, Morgane Mounier, Anne‐Sophie Woronoff, M. Daoulas, M. Robaszkiewicz, Jacqueline Clavel, Stéphanie Goujon, Brigitte Lacour, Isabelle Baldi, Camille Pouchieu, Brice Amadéo, Gaëlle Coureau, Sébastien Orazio, Alain Monnereau, Pierre‐Marie Preux, Faı̈za Rharbaoui, Émilie Marrer, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Sandrine Plouvier, Anne Cowppli‐Bony, Florence Molinié, S. Bara, O. Ganry, B. Lapôtre‐Ledoux, Pascale Grosclaude, Nadine Bossard, Zoé Uhry, Jacques Estève, Roland Stabenow, Heide Wilsdorf-Köhler, Andrea Eberle, Sabine Luttmann, I Löhden, Alice Nennecke, Joachim Kieschke, Eunice Sirri, Christina Justenhoven, Sylke Ruth Zeißig, B Holleczek, Nora Eisemann, Alexander Katalinic, R.A. Asquez, Vijay Kumar, Eleni Petridou, Laufey Tryggvadóttír, K.M. Clough-Gorr, Paul M. Walsh, H Sundseth, Guido Mazzoleni, Fabio Vittadello, Enzo Coviello, Francesco Cuccaro, Rocco Galasso, Giuseppe Sampietro, Adriano Giacomin, Michele Magoni, A Ardizzone, Angelo D’Argenzio, Marine Castaing, Giuseppe Grosso, Anna Maria Lavecchia, Angela Sardo, G Gola, Luciana V. Gatti, Paolo Ricci, Stefano Ferretti, Luigino Dal Maso, Diego Serraino, M V Celesia, Rosa Angela Filiberti, Fabio Pannozzo, Anna Melcarne, F Quarta, Anita Andreano, Antonio Russo, Giuliano Carrozzi, Claudia Cirilli, Luca Cavalieri d’Oro, M Rognoni, Maria Alice Fusco, Maria Francesca Vitale, M. Usala, Rosanna Cusimano, Walter Mazzucco, Maria Michiara, Paolo Sgargi, Lorenza Boschetti, Giorgio Chiaranda, Pietro Seghini, Milena Maule, Franco Merletti, ­Rosario ­Tumino, Pamela Mancuso, Massimo Vicentini, Tiziana Cassetti, Romano Sassatelli, Fabio Falcini, Sabrina Giorgetti, Anna Luisa Caiazzo, Rossella Cavallo, R. Cesaraccio, D Pirino, F. Bella, A Madeddu, Anna Clara Fanetti, S. Maspero, Simona Carone, Antonia Mincuzzi, Giuseppa Candela, T. Scuderi, Maria Gentilini, Silvano Piffer, Stefano Rosso, A Barchielli, Adele Caldarella, Fortunato Bianconi, Fabrizio Stracci, Paolo Contiero, Giovanna Tagliabue, Massimo Rugge, Manuel Zorzi, S Beggiato, A Brustolin, Roberta De Angelis, Roberto Zanetti, A Maurina, M Oniščuka, Seyed Mohsen Mousavi, N. A. Lipunova, Ieva Vincerževskienė, D. Agius, Neville Calleja, Sabine Siesling, Otto Visser, Siri Larønningen, Bjørn Møller, Agnieszka Dyzmann-Sroka, Maciej Trojanowski, Stanisław Góźdż, Tomasz Mierzwa, Łucja Molong, Jadwiga Rachtan, Sebastian Szewczyk, Jerzy Błaszczyk, Kamila Kępska, Beata Kościańska, R Amunicka, A Ostrowski, M. Zwierko, Wojciech Kaczmarek, K M Maksimowicz, E Purwin-Porowska, E Reca, J Wójcik-Tomaszewska, E Czajkowska, M Motnyk, Monika Grądalska-Lampart, A.U. Radziszewska, Anna Gos, Małgorzata Talerczyk, M Wyborska, Joanna Didkowska, Urszula Wojciechowska, Magdalena Bielska‐Lasota, G. Forjaz de Lacerda, R.A. Rego, Branca Carrito, A Pais, M J A T Bento, A. Mayer-da-Silva, A. Miranda, Mihaiela L. Blaga, Daniela Coza, L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, A. G. Egorova, А Е Орлов, L A Kudyakov, L. V. Pikalova, J Adamcik, C. Safaei Diba, Maja Primic‐Žakelj, Vesna Zadnik, Laís Moraes Gil, A A Herrera, D Rojas, R J Chillarón, A I M Navarro, M.L. Vilardell Gil, Esther Molina, P. Franch Sureda, M. Ramos Montserrat, M.D. Chirlaque, Carmen Navarro, Eva Ardanáz, Marcela Guevara, Adela Cañete-Nieto, M. Carulla, Jaume Galcerán, Fernando Almela, C Sabater, Saira Khan, David Pettersson, Paul W. Dickman, Katharina Staehelin, Benjamin Struchen, Céline Egger Hayoz, Christine Bouchardy, Robin Schaffar, Matthias Rössle, Jean‐Luc Bulliard, M. Maspoli-Conconi, Claudia E. Kuehni, Shelagh Redmond, Andrea Bordoni, Laura Ortelli, Arnaud Chioléro, Isabelle Konzelmann, Katarina L. Matthes, Sabine Rohrmann, John Broggio, Jem Rashbass, Deirdre Fitzpatrick, Anna Gavin, Donna Clark, A J Deas, D W Huws, M Matz, Pamela Minicozzi, Lisa Montel, Maja Nikšić, Naomi Ssenyonga, Richard Stephens, Elizabeth Chalker, Mark C. Smith, Richard Walton, Shuting Li, Stephanie Dugdale, Julie Moore, Shoni Philpot, Ruth M. Pfeiffer, Helen E. Thomas, B.C. Stokes, Alison Venn, Helen Farrugia, Vicky Thursfield, J. Dowling, David C. Currow, Christine Fowler, Christopher Lewis

Bibliographic record

VenueNeuro-Oncology · 2021
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsBC Cancer Agency
FundersInstituto Nacional do Câncer, Ministério da SaúdeCHILDREN with CANCER UKSaskatchewan Cancer AgencySusan G. Komen
KeywordsHistologyMedicinePopulationBrain tumorPediatricsPathologyEnvironmental health

Abstract

fetched live from OpenAlex

BACKGROUND: Global variations in survival for brain tumors are very wide when all histological types are considered together. Appraisal of international differences should be informed by the distribution of histology, but little is known beyond Europe and North America. METHODS: The source for the analysis was the CONCORD database, a program of global surveillance of cancer survival trends, which includes the tumor records of individual patients from more than 300 population-based cancer registries. We considered all patients aged 0-99 years who were diagnosed with a primary brain tumor during 2000-2014, whether malignant or nonmalignant. We presented the histology distribution of these tumors, for patients diagnosed during 2000-2004, 2005-2009, and 2010-2014. RESULTS: Records were submitted from 60 countries on 5 continents, 67 331 for children and 671 085 for adults. After exclusion of irrelevant morphology codes, the final study population comprised 60 783 children and 602 112 adults. Only 59 of 60 countries covered in CONCORD-3 were included because none of the Mexican records were eligible. We defined 12 histology groups for children, and 11 for adults. In children (0-14 years), the proportion of low-grade astrocytomas ranged between 6% and 50%. Medulloblastoma was the most common subtype in countries where low-grade astrocytoma was less commonly reported. In adults (15-99 years), the proportion of glioblastomas varied between 9% and 69%. International comparisons were made difficult by wide differences in the proportion of tumors with unspecified histology, which accounted for up to 52% of diagnoses in children and up to 65% in adults. CONCLUSIONS: To our knowledge, this is the first account of the global histology distribution of brain tumors, in children and adults. Our findings provide insights into the practices and the quality of cancer registration worldwide.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.638

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.286
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations38
Published2021
Admission routes2
Has abstractyes

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