Bibliographic record
Abstract
Myxoedema coma is a rare and life threatening medical emergency with a high mortality rate. It results from severe hypothyroidism and affects almost every organ system. The salient features of myxoedema coma are decreased mental status and hypothermia, but other characteristics of severe hypothyroidism are usually present including bradycardia, hypotension, hypoglycemia and hypoventilation. Abnormal accumulation of mucin in skin and other tissues can lead to typical clinical features, for example nonpitting oedema, swollen lips, enlarged tongue and thickened nose. Diagnosis is challenging due to the paucity of cases and possibly earlier recognition of hypothyroidism as a result of improved availability of thyrotropin (TSH) assays. Clinicians can be mislead by the misnomer “coma” as patients may present with signs of cognitive impairment such as agitation, confusion and disorientation. A high index of suspicions is needed among clinicians in order to rapidly recognize the condition and make an early diagnosis. Treatment should be commenced on clinical grounds while waiting for laboratory results. It is also vital that these patients receive intensive care level treatment with close monitoring of their cardiovascular parameters and level of consciousness. In addition, severe hypothyroidism can decompensate to myxoedema coma as a result of precipitating factors, for example cold exposure, alcohol, sedative drugs, sepsis or myocardial infarction. Therefore, it is important to address and try to reverse any of these precipitants. J Med Cases. 2013;4(11):715-718 doi: https://doi.org/10.4021/jmc1503w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".