O6- Methylguanine DNA Methyltransferase Activatable Photosensitizers for Cancer Therapeutics
Bibliographic record
Abstract
Photodynamic therapy (PDT) is minimally invasive medical procedure used for treatment of various cancers. PDT uses a small molecule photosensitizer (PS) that, when in the presence of molecular oxygen and light, can produce reactive oxygen species (ROS) that are toxic to cells. Over the past few years researchers have aimed to increase PDT cell specificity. Adding a secondary form of activation other than irradiation allows for disease-feature targeting, reducing off target effects. Enzyme-activatable PSs are one approach to add selectively over healthy tissues. In this study two novel O6-methylguanine-DNA methyltransferase (MGMT) activatable photosensitizers were synthesized and their fluorescent profiles were characterized in in vitro enzyme studies. These scaffolds provide the necessary foundational work for studies to continue in cells, as well as for development of future modifications on the same molecular backbone.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".