Development of an MRI-guided Robotic Platform and Optimized Treatment Parameters for Sonothrombolysis of Intraventricular Blood Clots
Bibliographic record
Abstract
Intraventricular haemorrhage develops in 3% of all live births in Canada and 50% of those babies develop post-haemorrhagic ventricular dilatation due to blood clots in the ventricles. This often leads to hydrocephalus, which can negatively impact an infant’s vision, hearing and long-term neurodevelopment. Current treatment involves invasive brain surgery that relieves the built-up pressure from hydrocephalus, but the clot is often left untreated. In this thesis, a robotically controlled focused ultrasound platform was evaluated as a method to perform sonothrombolysis of the clot. A range of focused ultrasound parameters were tested in vitro with porcine blood to determine what values effectively and efficiently induced sonothrombolysis. The robot’s current state was assessed and necessary changes to the hardware and software were implemented to bring the robot to a working condition. The thesis concludes with a robotically controlled focused ultrasound platform along with a set of optimized parameters recommended for sonothrombolysis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".