Sulfasalazine-Induced Pancytopenia Indicative of Bone Marrow Suppression: A Case Report
Bibliographic record
Abstract
Ulcerative colitis (UC) is a chronic disease characterized by the inflammation and ulceration of the colon mucosa. The present case report of pancytopenia associated with sulfasalazine treatment substantiates a few other published reports and further our knowledge of sulfasalazine tolerability. We report a case of sulfasalazine-induced pancytopenia indicative of bone marrow suppression in an 18 years old Saudi girl with UC. After two months of treatment with azathioprine, sulfasalazine and prednisolone, her hematological indicators declined to a greater extent. Initially, all medications except sulfasalazine were stopped but hematology did not improve so that sulfasalazine was also discontinued, but prednisolone was used for the next 30 days. Hematological indicators of the patient were improved and sulfasalazine was restarted at a dose of 500 mg t.i.d. However, within a month, hematological indicators declined drastically, which led to discontinuation of sulfasalazine re-treatment. The case of sulfasalazine-induced pancytopenia presented herein is suggestive of bone marrow suppression keeping in view the previous reports of UC patients regarding the development of sulfasalazine-induced bone marrow suppression and associated pancytopenia. J Med Cases. 2014;5(5):289-291 doi: http://dx.doi.org/ 10.14740 /jmc1767w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".