Bacterial DNA Induced TNF-alpha Expression in Buffaloes (Murrah) in Comparison to that of Cross Breed Cattle
Bibliographic record
Abstract
Buffaloes are generally considered to be disease resistance. But systematic studies to understand the underlying mechanism of disease resistance in buffaloes in comparison to that of cattle are scanty. Therefore, the present study was undertaken to study the immune response in terms of TNF-α expression in PBMCS isolated from buffaloes in comparison to that of cattle. PBMCs were isolated from blood collected from healthy buffaloes and cross breed cattle and incubated with bacterial (E.coli) DNA at different concentration for a different period of time. Total RNA was isolated and mRNA expression of TLR9 and TNF-α was studied. Expression of actin gen was studied as positive control. Incubation of PBMCs with bacterial DNA resulted in the expression of TLR9 in both, buffaloes and cattle. But, the expression of TNF-α was seen only in the case of buffaloes and the level was found to increase with the increase in bacterial DNA concentration and time. Thus this study reports the inherent difference in the immune response of buffaloes in comparison to that of cattle.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".