Bibliographic record
Abstract
Objective To identify and clone the gene encoding human ubiquitin binding enzyme and study its expression spectrum. Methods According to the sequence of human EST,which is highly homologous to the mouse ubiquitin conjugating enzyme(E2),primers used for library screening were synthesized to screen the human fetal brain cDNA library.The gene was analyzed by making use of bioinformatics and its expression spectrum was studied by using multiple tissue Northern blot. Results Two cDNA clones encoding human ubiquitin conjugating enzyme were isolated and identified.Both containing the ubiquitin conjugating domain,they were 88% identical in amino acid sequences and found to be isoforms of each other with only an exon excised from the short sequence.They belonged to a highly conserved,and widely expressed E2 enzyme family. Northern blot showed that they were expressed exclusively in heart,placenta,and pancreas while no transcripts could be detected in brain,lung,liver,skeletal muscle,or kidney. Conclusions The gene encoding human ubiquitin binding enzyme is expressed under both temporal and spatial control.As a key enzyme in the degradation of proteins,ubiquitin conjugating enzymes play a central role in the expression regulation on the level of post translation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".