Bibliographic record
Abstract
Esophagea l injury after ingestion of various drugs often goes unrecognized. T wo cases of te tracycline induced esophagitis are reported . T he main presenting symptoms were odynophagia and dysphagia for both solids and li4uiJs following the first two or three doses. Esophageal endoscopy revea led the rresence of acute esophageal ulce rs in both cases. Sympto mat ic re lief was achieved by discon t inuation of the drug and the use of viscous lidocaine and :mtnciJs. Recovery was compl ete within a few days. Recognition of rhis entity will help in its diagnosis and treatment, and should prevent further complicauons. Can J Gastroenterol 1989;3(4): 135137 Keys Words: Drug induced, Drug related, Esophagitis L'oesophagite medicamenteuse RESUME: II esr probable quc !es t raumatismes oesophagiens survenant apres \' ingestion de medicaments divers demeuren t souvent mcconnus. O n rapportc Jcux cas c.l'ocsophagite resultant de !'action de la tetracycl ine. Les principaux ~ymptomes rcve lateurs c taien t l'odynophagie et la dysphagie, pour les solides comme pour les liquides , a pres les deux ou trois premieres doses. U ne oesophagoscopie a revele la presence d'u lccres oesophagiens a igus dans ks deux cas. La crnation du medicament ct l'ac.lminist ra tio n de lidoca'inc v isqueuse et J'antiacides o nt amene une resolution des symptomes. La guerison fut complete cnquclques jours. Reconnaitre cette enti re a ide a en poser le d iagnostic, a cho isir le traitemem approprie e t pe rmct de prcvenir route autre complicat ion. Division of Gastroenterology. Oepartmcm of Medicine, Fawlty of Medicine; and Centre Hns/)italier Universitaire de Sherhrooke. Sherbrooke. Quebec Correspondence and reprints: Or Rene Beaudry. Faw/re de Medecine. 300 I . I 2ieme Avenue Nord, Sher'7rooke, Quebec}ll-f 5N4 . Telephone (8 19) 563-5555 ext 4612 Received for /)tlh/ication Febr,utry 21 . I 989. Accc/ned June I . I 989 CAN J GASTROENTERO L Vo1 3 No 4 SFPTEMRER 1989 ACUTI: ESOrl IA<..JTI~ FOLi OWINU ingest ion of caust ic substances 1s a well known entit y. However, drug relatec.l esophagn is rect.:ived attenti1m o nly in 1970, when Pemberton ( 1) dcscrihed l he first ca~e nf potassium induced esophagi tis. S ince l hen, th b t ypc of injury has been recognized as a consequence of ingestion n f several other meJications. T he followi ng cases illustrate the usual prcsenring picture. CASE PRESENTATION S Case one: A 23-year-old fema le patient presented wi th a four day history of dysphagia and oc.lynophagia for both sol ids and liquids. Four days earl ie r, Joxycycl ine, two tahlcts of I 00 mg each da ily, had been prescrihec.l for presumec.l c h lamydia ! vaginitis, subsequently found to be associated with Tornlo/)sis glaln·aw infec t io n. Med ica t io n was stopped by the patient after two doses as she was unable to swallow the capsules. Ph ys ica l exa min a ti o n was unremarkable. No candic.la infect ion was present in the mouth or pharynx.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.023 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".