Spontaneous Neurological Deterioration in Acute Cardioembolic Stroke: A Subgroup of Patients With Early Severe Prognosis
Bibliographic record
Abstract
Background : To determine clinical factors of spontaneous early neurological deterioration (END) and prognosis in a cohort of 480 consecutive patients with cardioembolic stroke (CS) without thrombolytic therapy hospitalized within 24 hours of the onset of symptoms . Methods : END was defined as a drop of ≥ 1 point in the Canadian Stroke Scale or ≥ 2 points in the Glasgow Coma Scale between admission and after 72 hours. All patients underwent computerized tomography and/or MRI examination. Results : END is present in 8.3% of CS patients. CS patients with END (n = 40) in comparison with patients without ND (n = 440) showed a worse early prognosis with statistically significant differences in absence of neurological deficit at hospital discharge (5% versus 17.3%), length of hospitalization (30.8 versus 18.5 days) and in-hospital mortality (47.5% versus 8.4%). In the multivariate analysis, early seizures, severe headache and hypertension were independent clinical predictors of END. Conclusions : In patients with CS, early seizures, severe headache and hypertension are clinical variables associated with END. CS with END constitutes a subgroup of patients with severe prognosis. Because most causes of worsening can be treated effectively, the deteriorating cardioembolic stroke patient merits a swift and incisive diagnostic and therapeutic approach. J Neurol Res. 2011;1(4):133-138 doi: https://doi.org/10.4021/jnr62w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".