Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on <i>Pseudomonas aeruginosa</i> biofilms and keratinocyte function
Bibliographic record
Abstract
Abstract Borate‐based glasses have generated great interest for wound healing applications due to their ability to incorporate biologically therapeutic ions which can then be released at the site of repair attributable to their high dissolution rates. In this study, the anti‐bacterial activity and cytocompatibility of sol‐gel–derived silver‐doped borate glasses (AgBGs) of the compositional range (60)B 2 O 3 –(36)CaO–(4–x)P 2 O 5 –(x)Ag 2 O, where x = 0.0, 0.3, 0.5, and 1 (mol.%) were investigated, in vitro . The dose‐dependent anti‐bacterial activity of AgBGs was demonstrated against Pseudomonas aeruginosa under both planktonic conditions and pre‐formed biofilms, with up to 99.7% reduction in bacterial cell counts. Lower concentrations of ionic dissolution products from AgBGs were non‐toxic to keratinocytes, stimulating their growth and metabolic activity. Furthermore, compositions containing 0.3 and 0.5 mol.% Ag significantly accelerated the migration of keratinocytes at two different concentrations in an in vitro 2D wound healing model. In summary, these therapeutic AgBGs have demonstrated potential for accelerated wound healing.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".