Eight Years Follow-up After Rush Specific Oral Tolerance Induction to Cow’s Milk Proteins
Bibliographic record
Abstract
Cow’s milk allergy (CMA) has a great impact on children and families quality of life. Recent studies point to a tendency for longer duration and greater severity. Specific oral tolerance induction (SOTI) to cow’s milk (CM) has been regarded as a promising strategy to improve care of these patients, but prospective data concerning tolerance and safety after ending SOTI are still lacking. The longest follow-up reported had the duration of 4 years. We report a case of a young male, now aged 20 year-old, with persistent CMA, successfully submitted to a rush SOTI CM protocol, which kept CM tolerance after 8 years. During this time he maintained daily CM ingestion and strictly followed doctor’s instructions. With a faster and easier to perform protocol we achieved the same efficacy as those reported before. The key to success could be the regular exposition to allergen. Publishing these case reports reinforces the safety and efficacy of SOTI therapeutic strategy. J Med Cases. 2012;3(1):31-33 doi: https://doi.org/10.4021/jmc400w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".