21. Making the World a Colourful Place: Exploration of the Key Condensation Enzymes in the Biosynthesis of Prodiginines and Tambjamines
Bibliographic record
Abstract
Bacteria produce many natural products that have useful bioactivities such as antibiotic, anticancer and antifungal effects. In bacteria, these molecules are made in a step-by-step process using proteins called enzymes that assist in building the molecule at each step of the process. This research is focusing on the biosynthesis of two classes of natural products called prodiginines and tambjamines. The molecules in each class have different structures but follow similar construction steps. Both processes first form the same common intermediate, then in the final step this intermediate is combined with another unique intermediate to make the final product. In this study, the enzyme that is involved in the final step of the process will be characterized for both prodiginine and tambjamine-type molecules. By purifying the enzymes for both types of molecule properties such as their catalytic mechanism, substrate flexibility, and structure can be determined and compared.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".