21. Making the World a Colourful Place: Exploration of the Key Condensation Enzymes in the Biosynthesis of Prodiginines and Tambjamines
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Bacteria produce many natural products that have useful bioactivities such as antibiotic, anticancer and antifungal effects. In bacteria, these molecules are made in a step-by-step process using proteins called enzymes that assist in building the molecule at each step of the process. This research is focusing on the biosynthesis of two classes of natural products called prodiginines and tambjamines. The molecules in each class have different structures but follow similar construction steps. Both processes first form the same common intermediate, then in the final step this intermediate is combined with another unique intermediate to make the final product. In this study, the enzyme that is involved in the final step of the process will be characterized for both prodiginine and tambjamine-type molecules. By purifying the enzymes for both types of molecule properties such as their catalytic mechanism, substrate flexibility, and structure can be determined and compared.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it