Sutureless dehydrated amniotic membrane for persistent epithelial defects
Why this work is in the frame
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Bibliographic record
Abstract
Purpose: To report outcomes of a sutureless dehydrated amniotic membrane for persistent epithelial defects (PED). Methods: This retrospective study included consecutive patients with a PED (⩾14 days) treated with a sutureless dehydrated amniotic membrane and bandage contact lens (BCL). Included were patients with an epithelial defect that did not respond to treatment with a BCL. Excluded were patients with a follow-up time of less than 3 months. Results: Nine eyes of eight patients with a mean age of 54.6 ± 10.9 years (range 38–73 years) were included in this study. The main etiology of the PED was limbal stem cell deficiency ( n = 5/9) due to Stevens-Johnson Syndrome ( n = 2/5), glaucoma procedures ( n = 1/5), graft-versus-host disease ( n = 1/5) and severe allergic reaction ( n = 1/5). Additional etiologies included neurotrophic cornea ( n = 2/9), post keratoplasty and severe dry eye disease ( n = 2/9). Time from PED presentation to amnion treatment was 65.9 ± 60.6 days (range 15–189 days) with the area of the PED being 11.0 ± 12.2 mm 2 (range 1.0–36.0 mm 2 ). The amnion was absorbed within 2 weeks in 100% of the cases. Following insertion of the amnion, resolution of the PED was achieved in 8/9 eyes (89%) without the need for additional interventions within 17.8 ± 9.6 days (range 7–35 days). LogMAR BCVA improved from 0.94 ± 0.88 to 0.37 ± 0.25 ( p = 0.036) with no complications or recurrences recorded. Conclusions: Sutureless dehydrated amniotic membrane achieved resolution of PEDs secondary to various etiologies in 89% of eyes with a significant improvement in vision demonstrated. Further studies are needed to assess long term safety and effectiveness.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it