Relationships between 12,13 Metabolites of Linoleic Acid and Cognitive Performance in Patients with Type 2 Diabetes Mellitus
Bibliographic record
Abstract
Background: Type 2 diabetes mellitus (T2DM) is linked with diabetes-related cognitive decline. Oxylipins are bioactive molecules derived from polyunsaturated free fatty acids. Hydrolysis of cytochrome p450-derived epoxides into diols by soluble epoxide hydrolase (sEH) are of relevant interest due to their involvement in diabetic microvascular disease. Methods: This thesis examines peripheral concentrations of 12,13-species of linoleic acid (LA)-derived oxylipins and associations with cognitive performance in patients with T2DM or prediabetes. Cognition was assessed through multiple cognitive tests evaluating domains including executive function and memory. Serum oxylipin concentrations were measured via ultra-high-performance liquid chromatography tandem mass-spectrometry. Results: Serum concentrations of 12(13)-EpOME and 12,13-DiHOME were negatively associated with executive function. Serum concentrations of 12(13)-EpOME were also negatively associated with verbal memory. Conclusions: In T2DM, concentrations of 12,13-species of LA-derived oxylipins were negatively associated with cognitive performance, suggesting a possible role in the pathogenesis of diabetes-related cognitive decline.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".