THE IMPACT OF ANTIHYPERTENSIVE DRUGS ON VASCULAR RIGIDITY AND ON THE GRADIENTS OF ARTERIAL STIFFNESS: A PILOT STUDY
Bibliographic record
Abstract
Objective: Damages to barosensitive organs would be induced by the reversal of the arterial stiffness gradient. Our team has demonstrated that administration of nitroglycerin reduces regional stiffness of muscle arteries (radial and femoral) without modifying aortic stiffness, resulting in increased aortic-brachial (AB-PWV) and aortic-femoral (AF-PWV) stiffness gradients. The aim of this project is to study the impact of antihypertensive treatment on arterial stiffness, particularly on stiffness gradients. Design and method: This pilot study was performed in 19 hypertensive patients (age: 71 ± 11 years, men: 85%). The aortic, brachial and femoral stiffnesses were respectively measured by the carotid-femoral (cf-PWV), carotid-radial (cr-PWV) and femoral-dorsalis pedis (fd-PWV) pulse wave velocity during 2 visits: with and without medication for high blood pressure. During the drug-free visit, patients were to stop taking their antihypertensive drugs 2-3 days before their assessment, depending on their condition. The AB-PWV and AF-PWV ratios were obtained by dividing cf-PWV by cr-PWV or fd-PWV respectively. Results: At the visit without antihypertensive drugs, the cf-PWV, cr-PWV and fd-PWV were respectively 12.91 ± 0.65 m/s, 9.6 ± 0.4 m/s and 10.3 ± 0.3 m/s, resulting in an AB- ratio PWV of 1.37 ± 0.09 and an AF-PWV ratio of 1.21 ± 0.07. At the visit with medication, a significant decrease in mean arterial pressure of 9.5 mmHg (p < 0.001) was observed. In addition, reductions in cr-PWV of 0.79 m/s (p = 0.034) and fd-PWV of 0.45 m/s (p = 0.29) were noted, with no statistically significant change in cf-PWV (p = 0.83), leading to a non-significant increase in the AB-PWV (p = 0.21) and AF-PWV (p = 0.52) ratios. Conclusions: The preliminary data from this pilot project, although statistically non-significant, evolves in the same direction as those obtained with the administration of nitroglycerin. Indeed, there is a decrease in brachial and femoral stiffness leading to an increase in the gradients, which could have consequences for the microcirculation. These results suggest an impact of antihypertensive drugs on peripheral arteries and the vascular stiffness gradients, which could be confirmed with the continuation of this project on a larger sample.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".