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Record W3158372074 · doi:10.15173/sciential.v1i4.2423

Bioethical Analysis of Gene Editing

2020· article· en· W3158372074 on OpenAlex
Caitlin Marie Reintjes, Isabel Dewey

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
venuePublished in a venue whose home country is Canada.

Bibliographic record

VenueSciential - McMaster Undergraduate Science Journal · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsMcMaster University
Fundersnot available
KeywordsEugenicsBioethicsGenome editingBiologyIdeologyEnvironmental ethicsAltruism (biology)GeneticsGeneSociologyPolitical scienceEvolutionary biologyCRISPRPoliticsLawPhilosophy

Abstract

fetched live from OpenAlex

New developments in gene editing methods include the possibility to alter embryos for disease resistance. This could allow for increased immunity in the future, but at what cost? Gene editing may have unintended consequences. Some alterations may prevent the development of one disease but increase susceptibility to another. Other genes persist in populations for complex evolutionary reasons. Scientists must therefore consider the consequences and bioethics associated with these genetic changes. With examples such as the CCR5 coreceptor and major histocompatibility complex, it becomes clear that this type of genetic enhancement is immoral when evaluating it from biological, evolutionary, social, and economic perspectives. First, having the ability to select for certain desirable genes limits genetic diversity, which creates a barrier for evolution. Selecting for certain genes perpetuates the concept of ideal genes resembling dangerous eugenic ideologies. Should these procedures become more prevalent, the issue of accessibility arises. If these expensive procedures are only available to those who can afford them, the opportunity gap between the poor and the rich will widen. An investigation of case studies and ethical implications demonstrates that genomic editing is immoral and impermissible.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.277
Threshold uncertainty score0.442

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.002
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.316
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it