Evaluation of Radium 223 Dichloride adsorption to unit dose syringes
Bibliographic record
Abstract
2671 Objectives Radium 223 dichloride is gaining momentum in its utility for radiotherapy of castration-resistant prostate cancer patients with bone metastases. This study aimed to examine the effect of incubation time and saline rinsing on the retention of activity in unit dose syringes used in clinical practice in our facility. Methods Radium 223 dichloride doses were dispensed into 10cc and 5cc BD syringes and left to sit at room temperature for 1h, 24 hrs, 48 hrs, 72 hrs, and 168 hrs. After incubation, the syringes were emptied into vials and rinsed three times with saline. All syringes were assayed before and after emptying and between rinses. Planar imaging was used to localize the residual activity within the emptied syringe. Results The amount of residual activity in the syringes was found to be independent of the radium 223 dichloride solution incubation time. A significant portion of residual activity could be removed by one full rinse of the syringe and needle. Planar imaging of emptied syringe showed that most of the activity was retained in the luer lock needle hub and plunger. Conclusions The incubation time does not seem to affect the degree of retention of radium 223 dichloride solution into the syringes tested. At least one saline rinse is necessary to decrease the residual activity in the syringe. Images showed that initial activity retention after emptying was located in the needle hub and plunger and that, after rinsing, residual activity was isolated within the luer lock needle hub.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".