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Record W3160562888 · doi:10.1101/2021.05.14.21256707

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimer’s disease: A cross-cohort comparison and Mendelian randomization meta-analysis

2021· preprint· en· W3160562888 on OpenAlexaff
Roxanna Korologou‐Linden, Bing Xu, Elizabeth Coulthard, Esther Walton, Alfie Wearn, Gibran Hemani, Tonya White, Charlotte A. M. Cecil, Tamsin Sharp, Henning Tiemeier, Tobias Banaschewski, Arun L.W. Bokde, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean‐Luc Martinot, Marie‐Laure Paillère Martinot, Éric Artiges, Frauke Nees, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Günter Schumann, Laura D Howe, Yoav Ben‐Shlomo, Neil M Davies, Emma L. Anderson

Bibliographic record

VenuemedRxiv · 2021
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversité de MontréalCentre Hospitalier Universitaire Sainte-JustineUniversity of Toronto
FundersNational Institute of Mental HealthEconomic and Social Research CouncilMedical Research CouncilNational Institutes of Health
KeywordsMendelian randomizationNeurodegenerationAlzheimer's diseaseBrain sizeDementiaAtrophyDiseaseBrain morphometryNeuroscienceWhite matterPsychologyMedicineInternal medicineBiologyMagnetic resonance imagingGeneticsGenetic variants

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.035
metaresearch head score (Gemma)0.036
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.035
Threshold uncertainty score0.185

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0350.036
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.024
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.342
Teacher spread0.315 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2021
Admission routes1
Has abstractyes

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Same venuemedRxiv→Same topicGenetic Associations and Epidemiology→French-language works237,207→