Carbon quantum dots/Bi <sub>4</sub> O <sub>5</sub> Br <sub>2</sub> photocatalyst with enhanced photodynamic therapy: killing of lung cancer (A549) cells in vitro
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Inorganic photocatalysts have been regarded as a promising candidate in the domain of tumor photodynamic therapy (PDT) due to their inspirational photocatalytic activity. In this study, a Bi 4 O 5 Br 2 photocatalyst was synthesized and it exhibited effective photo‐killing activity of A549 cells (a human lung carcinoma epithelial cell line) in vitro. On this basis, we modified Bi 4 O 5 Br 2 with carbon quantum dots (CQDs) via a hydrolysis method at room temperature, which resulted in an improved photo‐killing effect of Bi 4 O 5 Br 2 to A549 cells. The samples and the interaction between samples and cells were fully characterized. It has been found that the loading of CQDs on Bi 4 O 5 Br 2 can reduce the hydration ratio, increase the cellular uptake and improve the photogenerated reactive oxygen species (ROS) as compared with pristine Bi 4 O 5 Br 2 . Electron spin resonance (ESR) analysis and radical‐trapping experiments manifested that the ROS contributed to PDT may be ·O 2 − and ·OH. This study may provide a useful strategy to ameliorate the penetrability, cell compatibility and PDT effect upon cancer cells of other inorganic photocatalysts.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it