Detection of Post-Traumatic Stress Disorder Using Learned Time-Frequency Representations from Pupillometry
Bibliographic record
Abstract
Post-traumatic stress disorder is a major public health concern with a lifetime prevalence rate of 6.1-9.2% in North America. PTSD is known to alter the autonomic nervous system leading to chronic sympathetic arousal including heightened anxiety and hypervigilance. Pupillometry offers a quick and accessible measure of autonomic nervous system imbalances characteristic of PTSD. This study investigates the utility of pupillometry as a biomarker to detect PTSD in a sample of 39 adults with (n = 22) and without (n = 17) PTSD. Participants viewed a 25-minute computer protocol consisting of 5-minute rest phase, 10-minute negative emotionally valent images, and 10-minute guided meditation. We relied on a time-frequency analysis to represent the pupillary responses of two different groups (PTSD-affected individuals and healthy-control subjects). These data were then employed with a CNN network to learn a prediction model. Individuals with PTSD demonstrated increased pupil dilation across the entire protocol. The final outcome revealed an accuracy of 81.09% which indicates the feasibility of using this approach to detecting participants with PTSD in an automated way. Findings from this research have important implications for clinical mental health assessment, diagnostics and treatment.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".