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Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas U. Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Åke Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Ophélie Bertrand, Sandrine M. Caputo, Anaïs Dupré, Marine Le Mentec, Muriel Belotti, Anne‐Marie Birot, Bruno Buecher, Emmanuelle Fourme, Marion Gauthier‐Villars, Lisa Golmard, Claude Houdayer, Virginie Moncoutier, Antoine De Pauw, Claire Saule, Olga M. Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, Mélanie Léone, Nadia Boutry‐Kryza, Alain Calender, Sophie Giraud, Olivier Caron, Marine Guillaud‐Bataille, Brigitte Bressac–de Paillerets, Yves Jean Bignon, Nancy Uhrhammer, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Dominique Vaur, Laurent Castéra, Tetsuro Noguchi, Cornel Popovici, Hagay Sobol, Violaine Bourdon, Audrey Remenieras, Catherine Noguès, Isabelle Coupier, Pascal Pujol, Aurélie Dumont, Françoise Révillion, Claude Adenis, Danièle Muller, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sévenet, Michel Longy, Christine Toulas, Rosine Guimbaud, Laurence Gladieff, V. Feillel, Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon, Fanny Coron, Laurence Faivre, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Sarab Lizard, Fabienne Prieur, Marine Lebrun, Sandra Fert Ferrer, Véronique Mari, Laurence Venat‐Bouvet, Capucine Delnatte, Stéphane Bezieau, Isabelle Mortemousque, Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin, Johanna Sokolowska, Myriam Bronner, Marie‐Agnès Collonge‐Rame, Alexandre Damette, Paul Gesta, Hakima Lallaoui, Jean Chiésa, Denise Molina‐Gomes, Olivier Ingster, Helen Gregory, Zosia Miedzybrodzka, Patrick J. Morrison, Kai-Ren Ong, Alan Donaldson, Mark T. Rogers, Mary Porteous, Carole Brewer, Rosemarie Davidson, Louise Izatt, Angela Brady, Julian Barwell, Julian Adlard, Claire Foo, Fiona Lalloo, Lucy Side, Jacqueline Eason, Alex Henderson, Lisa Walker, Rosalind A. Eeles, Jackie Cook, Katie Snape, Diana Eccles, Alex Murray, Emma McCann, Margriet Collée, Don Conroy, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Dı́ez, Yuan Chun Ding, Susan M. Domchek, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Miriam Dwek, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago-Domínguez, Susan M. Gapstur, Judy E. Garber, Vanesa García‐Barberán, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Simon A. Gayther, Andrea Gehrig, V. Georgoulias, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia Harrington, Steven N. Hart, Wei He, Frans B.L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Darling J Horcasitas, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, Stephen B. Fox, Ian Campbell, Amanda B. Spurdle, Anna de Fazio, Margaret Tassell, Judy Kirk, Geoffrey J. Lindeman, Melanie A. Price, Melissa C. Southey, Roger L. Milne, Sid Deb, David D.L. Bowtell, Annemieke H. van der Hout, Ans M.W. van den Ouweland, Arjen R. Mensenkamp, Carolien H. M. van Deurzen, Carolien M. Kets, Caroline Seynaeve, Christi J. van Asperen, Cora M. Aalfs, E. Gómez, Flora E. van Leeuwen, Geertruida H. de Bock, Hanne Meijers‐Heijboer, Inge Marie Obdeijn, Jan C. Oosterwijk, Juul Wijnen, Lizet E. van der Kolk, Maartje J. Hooning, Margreet G.E.M. Ausems, Marian J.E. Mourits, Marinus J. Blok, Matti A. Rookus, Rob B. van der Luijt, T. C. T. E. F. van Cronenburg, Carmen C. van der Pol, Nicola S. Russell, Sabine Siesling, Lucy Overbeek, R. Wijnands, Judith L. de Lange, J. Dinny Graham, Mythily Sachchithananthan, Deborah J. Marsh, Rodney J. Scott, Robert C. Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, Agnes Jager, Anna Jakubowska, Paul A. James, Uffe Birk Jensen, Esther M. John, Michael E. Jones, Rudolf Kaaks, Pooja Middha, Beth Y. Karlan, Renske Keeman, Э. К. Хуснутдинова, Johanna I. Kiiski, Yon-Dschun Ko, Veli‐Matti Kosma, Peter Kraft, Allison W. Kurian, Yael Laitman, Diether Lambrechts, Loı̈c Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adrià López‐Fernández, Jennifer T. Loud, Craig Luccarini, Siranoush Manoukian, Sara Margolin, John W.M. Martens, Noura Mebirouk, Alfons Meindl, Austin Miller, Marco Montagna, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Finn Cilius Nielsen, Katie M. O’Brien, Olufunmilayo I. Olopade, Janet E. Olson, Håkan Olsson, Ana Osório, Laura Ottini, Tjoung‐Won Park‐Simon, Michael T. Parsons, Inge Søkilde Pedersen, Beth N. Peshkin, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Kelly‐Anne Phillips, Eric C. Polley, Bruce Poppe, Nadège Presneau, Miguel Ángel Pujana, Kevin Punie, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Hedy S. Rennert, Mark E. Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Dale P. Sandler, Regina M. Santella, Maren T. Scheuner, Marjanka K. Schmidt, Gunnar Schmidt, Christopher G. Scott, Priyanka Sharma, Penny Soucy, John J. Spinelli, Zoe Steinsnyder, Jennifer Stone, Dominique Stoppa‐Lyonnet, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Àlex Teulé, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Alison H. Trainer, Thérèse Truong, Nadine Tung, Celine M. Vachon, Ana Vega, Joseph Vijai, Qin Wang, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Camilla Wendt, Alicja Wolk, Siddhartha Yadav, Xiaohong R. Yang, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Sue K. Park, Mads Thomassen, Kenneth Offit, Rita K. Schmutzler, Fergus J. Couch, Jacques Simard, Georgia Chenevix‐Trench, Douglas F. Easton, Nadine Andrieu, Antonis C. Antoniou
Bibliographic record
VenueNature Communications · 2021
Typeerratum
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNutrition, Genetics, and Disease
Canadian institutionsUniversity of British ColumbiaUniversité LavalCentre hospitalier universitaire de QuébecMcGill UniversityUniversity of TorontoRoyal Victoria HospitalQueen's UniversityLunenfeld-Tanenbaum Research InstituteMount Sinai Hospital
FundersNational Center for Advancing Translational SciencesNational Institute of General Medical SciencesCancer Research UK
KeywordsBreast cancerMutationGeneticsMedicineOncologyBioinformaticsComputational biologyCancerBiologyGene
Abstract
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.065
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.028
Threshold uncertainty score0.093
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.065 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.003 | 0.001 |
| Research integrity | 0.005 | 0.007 |
| Insufficient payload (model declined to judge) | 0.028 | 0.009 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.017
GPT teacher head0.354
Teacher spread0.336 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations0
Published2021
Admission routes1
Has abstractyes